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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 1(49), p. 406-407, 2005

DOI: 10.1128/aac.49.1.406-407.2005

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Serine-to-Asparagine Substitution in the GyrA Gene Leads to Quinolone Resistance in Moxifloxacin-Exposed Chlamydia pneumoniae

Journal article published in 2004 by Jan Rupp, Andreas Gebert, Werner Solbach ORCID, Matthias Maass
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Quinolone resistance of Chlamydia pneumoniae has not been described previously. Serial subcultures of C. pneumoniae under increasing moxifloxacin concentrations (0.0125 to 6.4 mg/liter) resulted in a 256-fold MIC increase compared to moxifloxacin-naive strains. GyrA gene sequencing revealed a novel point mutation with a Ser→Asn substitution. Subcultures under rifalazil and macrolides did not alter the respective MICs.