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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 1(49), p. 425-427, 2005

DOI: 10.1128/aac.49.1.425-427.2005

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In-House Phage Amplification Assay Is a Sound Alternative for Detecting Rifampin-Resistant Mycobacterium tuberculosis in Low-Resource Settings

Journal article published in 2005 by N. S¡mboli, Norberto Simboli, Norberto Símboli, Howard Takiff, Ruth McNerney ORCID, Beatriz López, Anandi Martin, Juan Carlos Palomino, Lucía Barrera, Viviana Ritacco
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT An in-house mycobacteriophage amplification assay for detecting rifampin-resistant Mycobacterium tuberculosis showed 100% sensitivity, 97.7% specificity, and 95.2% predictive value for resistance in a test of 129 isolates from a hot spot area of multidrug-resistant M. tuberculosis . The applicability of the test was demonstrated in the routine work flow of a low-resource reference laboratory.