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Springer, Journal of Autism and Developmental Disorders, 9(39), p. 1291-1297, 2009

DOI: 10.1007/s10803-009-0743-2

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Using the Autism-Spectrum Quotient to Discriminate Autism Spectrum Disorder from ADHD in Adult Patients With and Without Comorbid Substance Use Disorder

Journal article published in 2009 by Bram B. Sizoo ORCID, Wim van den Brink, W. van den Brink, Marielle Gorissen van Eenige, Marielle E. E. Gorissen-Van Eenige, Maarten W. Koeter, Patricia J. M. van Wijngaarden-Cremers, P. J. van Wijngaarden-Cremers, Rutger Jan van der Gaag, R. J. van der Gaag
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Abstract

It is unknown whether the Autism-spectrum quotient (AQ) can discriminate between Autism Spectrum Disorder (ASD) and Attention Deficit and Hyperactivity Disorder (ADHD) with or without comorbid Substance Use Disorder (SUD). ANOVA’s were used to analyse the mean AQ (sub)scores of 129 adults with ASD or ADHD. We applied receiver operating characteristic (ROC) computations to assess discriminant power. All but one of the mean AQ (sub)scores were significantly higher for adults with ASD compared to those with ADHD. The SUD status in general was not significantly associated with AQ (sub)scores. On the Social Skills subscale patients with ASD and comorbid SUD showed less impairment than those without SUD. The cut-off score 26 yielded 73% correct classifications. The clinical use of the AQ in differentiating between ASD and ADHD is limited.