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Oxford University Press, Nucleic Acids Research, 8(33), p. 2384-2394, 2005

DOI: 10.1093/nar/gki534

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Independent binding sites of small protein B onto transfer-messenger RNA during trans-translation

Journal article published in 2005 by Marc Hallier, Laurent Metzinger ORCID, Brice Felden
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Stalled bacterial ribosomes are freed by transfer-messenger RNA (tmRNA). With the help of small protein B (SmpB), protein synthesis restarts and tmRNA adds a tag to the stalled protein for destruction. The conformation of a 347 nt long tmRNA from a thermophile and its interactions with SmpB were monitored using structural probes. The RNA is highly folded, including the reading frame, with