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Nature Research, Nature Neuroscience, 11(18), p. 1556-1558, 2015

DOI: 10.1038/nn.4126

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CD33 modulates TREM2: convergence of Alzheimer loci

Journal article published in 2015 by Gail Chan, Charles C. White, Phoebe A. Winn, Maria Cimpean ORCID, Joseph M. Replogle ORCID, Laura R. Glick, Nicole E. Cuerdon, Katie J. Ryan, Keith A. Johnson, Julie A. Schneider, David A. Bennett, Lori B. Chibnik, Reisa A. Sperling, Elizabeth M. Bradshaw ORCID, Philip L. De Jager
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Here, we report results from a protein quantitative trait analysis in monocytes from 226 individuals to evaluate cross-talk between Alzheimer loci. We find that the NME8 locus influences PTK2B and that the CD33 risk allele leads to greater TREM2 expression. Further, we observe (1) a decreased TREM1/TREM2 ratio with a TREM1 risk allele, (2) decreased TREM2 expression with CD33 suppression, and (3) elevated cortical TREM2 mRNA expression with amyloid pathology.