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Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.
Journal article published in 2007 by
Emma Jaeger,
Emily Webb,
Kimberley Howarth,
Luis Carvajal-Carmona,
Andrew Rowan,
Peter Broderick 
,
Axel Walther,
Sarah Spain ,
Alan Pittman,
Zoe Kemp,
Kate Sullivan,
Karl Heinimann,
Steven Lubbe,
Enric Domingo,
Ella Barclay
and other authors.
,
Axel Walther,
Sarah Spain ,
Alan Pittman,
Zoe Kemp,
Kate Sullivan,
Karl Heinimann,
Steven Lubbe,
Enric Domingo,
Ella Barclay
and other authors.
Abstract
We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)).