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Elsevier, Vaccine, 12(30), p. 2083-2089, 2012

DOI: 10.1016/j.vaccine.2012.01.053

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The influence of BCG vaccine strain on mycobacteria-specific and non-specific immune responses in a prospective cohort of infants in Uganda

Journal article published in 2012 by Elizabeth J. Anderson, Emily L. Webb, Patrice A. Mawa, Moses Kizza, Nancy Lyadda, Margaret Nampijja ORCID, Alison M. Elliott
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Abstract

► Largest study comparing BCG strains and first to assess strain effects on non-specific responses. ► Cytokine responses to both mycobacterial and non-mycobacterial stimuli are strain-dependent. ► BCG-Denmark causes higher cytokine levels and more scars and adverse events than two other strains. ► Sex may interact with the effect of strain; non-specific responses are not associated with scars. ► BCG strain choice may be important and should be evaluated in novel vaccine strategies using BCG.