Published in
Oxford University Press, The Journal of Infectious Diseases, 2(208), p. 340-345, 2013
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Comparison of Modeling Methods to Determine Liver-to-blood Inocula and Parasite Multiplication Rates During Controlled Human Malaria Infection
Journal article published in 2013 by
Alexander D. Douglas,
Nick J. Edwards 
,
Christopher Ja A. Duncan,
Fiona M. Thompson,
Susanne H. Sheehy,
Geraldine A. O'Hara,
Nicholas Anagnostou,
Michael Walther,
Daniel P. Webster,
Susanna J. Dunachie,
David W. Porter,
Laura Andrews,
Sarah C. Gilbert,
Simon J. Draper ,
Adrian Vs S. Hill
and other authors.
,
Christopher Ja A. Duncan,
Fiona M. Thompson,
Susanne H. Sheehy,
Geraldine A. O'Hara,
Nicholas Anagnostou,
Michael Walther,
Daniel P. Webster,
Susanna J. Dunachie,
David W. Porter,
Laura Andrews,
Sarah C. Gilbert,
Simon J. Draper ,
Adrian Vs S. Hill
and other authors.
This paper is made freely available by the publisher.
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Abstract
Controlled human malaria infection is used to measure efficacy of candidate malaria vaccines before field studies are undertaken. Mathematical modeling using data from quantitative polymerase chain reaction (qPCR) parasitemia monitoring can discriminate between vaccine effects on the parasite's liver and blood stages. Uncertainty regarding the most appropriate modeling method hinders interpretation of such trials.