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American Association for the Advancement of Science, Science, 5834(317), p. 130-132, 2007

DOI: 10.1126/science.1142311

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Host Resistance to Lung Infection Mediated by Major Vault Protein in Epithelial Cells

Journal article published in 2007 by Michael P. Kowalski, Anne Dubouix-Bourandy, Milan Bajmoczi, David E. Golan, Tanweer Zaidi, Yamara S. Coutinho-Sledge, Melanie P. Gygi, Steven P. Gygi, Erik A. C. Wiemer ORCID, Gerald B. Pier
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The airway epithelium plays an essential role in innate immunity to lung pathogens. Ribonucleoprotein particles primarily composed of major vault protein (MVP) are highly expressed in cells that encounter xenobiotics. However, a clear biologic function for MVP is not established. We report here that MVP is rapidly recruited to lipid rafts when human lung epithelial cells are infected with Pseudomonas aeruginosa , and maximal recruitment is dependent on bacterial binding to the cystic fibrosis transmembrane conductance regulator. MVP was also essential for optimal epithelial cell internalization and clearance of P. aeruginosa . These results suggest that MVP makes a substantial contribution to epithelial cell–mediated resistance to infection.