Published in
BioMed Central, BMC Cancer, 1(14), 2014
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Serial enumeration of circulating tumor cells predicts treatment response and prognosis in metastatic breast cancer: a prospective study in 393 patients
Journal article published in 2014 by
Markus Wallwiener,
Sabine Riethdorf,
Andreas Daniel Hartkopf,
Caroline Modugno,
Juliane Nees,
Dharanija Madhavan,
Martin Ronald Sprick 
,
Sarah Schott,
Christoph Domschke,
Irène Baccelli,
Barbara Burwinkel,
Birgitt Schönfisch,
Frederik Marmé,
Jörg Heil ,
Christof Sohn
and other authors.
,
Sarah Schott,
Christoph Domschke,
Irène Baccelli,
Barbara Burwinkel,
Birgitt Schönfisch,
Frederik Marmé,
Jörg Heil ,
Christof Sohn
and other authors.
This paper is made freely available by the publisher.
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Abstract
Abstract Background To prospectively assess circulating tumor cell (CTC) status at baseline (CTC BL ) and after one cycle of a new line of systemic therapy (CTC 1C ), and changes from CTC BL to CTC 1C (CTC kinetics, CTC KIN ) for their utility in predicting response, progression-free (PFS) and overall survival (OS) in metastatic breast cancer (MBC). Methods CTC BL and CTC 1C status was determined as negative (-) or positive (+) for