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American Academy of Neurology (AAN), Neurology, 13(82), p. 1187-1189, 2014

DOI: 10.1212/wnl.0000000000000273

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CNS inflammation other than multiple sclerosis: How likely is diagnosis?

Journal article published in 2014 by Christopher A. Halfpenny, Duncan Street ORCID, Ian Galea
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The incidence, diagnostic landscape, and workload impact of CNS inflammatory diseases other than multiple sclerosis (MS) (CIDOMS) in a tertiary setting is unknown. We describe a retrospective case series of 64 patients identified over a 2-year period (2009–2010) at the Wessex Neurological Centre in the United Kingdom, accounting for 4% of all patients seen at the center. As expected, neurosarcoidosis and neuromyelitis optica (NMO) were the commonest diagnoses reached (14% each); other diagnoses singly accounted for >10%. However, the likeliest diagnostic outcome (strikingly, in 25%) was nondiagnosis, despite intensive investigation and a mean follow-up period of 3 years. Undiagnosed CIDOMS patients represented the largest workload of the neurology center.