Elsevier, Preventive Medicine, (77), p. 150-154, 2015
DOI: 10.1016/j.ypmed.2015.05.025
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•The classic cardiac risk scores are based on factors associated with atherosclerosis.•We test atherosclerosis as a mediator between risk scores and cardiac damage.•The more accurate a score is, the less it is mediated by atherosclerosis.•The association with atherosclerosis limits the accuracy of cardiac risk scores.•Atherosclerosis is not a good prognostic precursor of cardiac events.