Published in
American Society for Cell Biology, Molecular Biology of the Cell, 17(24), p. 2703-2713
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- American Society for Cell Biology | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
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Plasma membrane domains enriched in cortical endoplasmic reticulum function as membrane protein trafficking hubs
Journal article published in 2013 by
Philip D. Fox,
Christopher J. Haberkorn,
Aubrey V. Weigel 
,
Jenny L. Higgins,
Elizabeth J. Akin,
Matthew J. Kennedy,
Diego Krapf,
Michael M. Tamkun
,
Jenny L. Higgins,
Elizabeth J. Akin,
Matthew J. Kennedy,
Diego Krapf,
Michael M. Tamkun
This paper is made freely available by the publisher.
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Abstract
This study investigates the hypothesis that trafficking of membrane proteins occurs at plasma membrane (PM) domains adjacent to underlying cortical endoplasmic reticulum (cER). The authors observe exocytosis of transferrin receptor and vesicular stomatitis virus G-protein to occur preferentially (>80%) at cER-enriched PM domains. They also report a preferential (>80%) localization of clathrin-coated pits at these domains.