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MyJove Corporation, Journal of Visualized Experiments, 54, 2011

DOI: 10.3791/2809-v

MyJove Corporation, Journal of Visualized Experiments, 54

DOI: 10.3791/2809

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Identification and Analysis of Mouse Erythroid Progenitors using the CD71/TER119 Flow-cytometric Assay

Journal article published in 2011 by Miroslav Koulnis, Ramona Pop, Ermelinda Porpiglia, Jeffrey R. Shearstone, Daniel Hidalgo, Merav Socolovsky ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The study of erythropoiesis aims to understand how red cells are formed from earlier hematopoietic and erythroid progenitors. Specifically, the rate of red cell formation is regulated by the hormone erythropoietin (Epo), whose synthesis is triggered by tissue hypoxia. A threat to adequate tissue oxygenation results in a rapid increase in Epo, driving an increase in erythropoietic rate, a process known as the erythropoietic stress response. The resulting increase in the number of circulating red cells improves tissue oxygen delivery. An efficient erythropoietic stress response is therefore critical to the survival and recovery from physiological and pathological conditions such as high altitude, anemia, hemorrhage, chemotherapy or stem cell transplantation.