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Oxford University Press, SLEEP, 4(37), p. 811-819, 2014

DOI: 10.5665/sleep.3596

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Trazodone Increases the Respiratory Arousal Threshold in Patients with Obstructive Sleep Apnea and a Low Arousal Threshold

Journal article published in 2014 by Danny J. Eckert ORCID, Atul Malhotra, Andrew Wellman, David P. White
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The effect of common sedatives on upper airway physiology and breathing during sleep in obstructive sleep apnea (OSA) has been minimally studied. Conceptually, certain sedatives may worsen OSA in some patients. However, sleep and breathing could improve with certain sedatives in patients with OSA with a low respiratory arousal threshold. This study aimed to test the hypothesis that trazodone increases the respiratory arousal threshold in patients with OSA and a low arousal threshold. Secondary aims were to examine the effects of trazodone on upper airway dilator muscle activity, upper airway collapsibility, and breathing during sleep.