Published in
American Society of Hematology, Blood, 14(127), p. 1743-1751, 2016
DOI: 10.1182/blood-2015-07-661371
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- American Society of Hematology | PDF
- [europepmc.org] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Dicer1 mediated miRNA processing shapes the mRNA profile and function of murine platelets
Journal article published in 2016 by
Jesse W. Rowley,
Stéphane Chappaz 
,
Aurélie Corduan,
Mark M. W. Chong,
Robert Campbell,
Amanda Khoury,
Bhanu Kanth Manne,
Jeremy G. T. Wurtzel,
James V. Michael,
Lawrence E. Goldfinger,
Michele M. Mumaw,
Marvin T. Nieman,
Benjamin Thomas Kile ,
Patrick Provost ,
Andrew S. Weyrich
,
Aurélie Corduan,
Mark M. W. Chong,
Robert Campbell,
Amanda Khoury,
Bhanu Kanth Manne,
Jeremy G. T. Wurtzel,
James V. Michael,
Lawrence E. Goldfinger,
Michele M. Mumaw,
Marvin T. Nieman,
Benjamin Thomas Kile ,
Patrick Provost ,
Andrew S. Weyrich
This paper is made freely available by the publisher.
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Abstract
Key PointsDicer1 deletion in MKs alters platelet miRNA and mRNA profiles. Dicer1-deficient platelets display increased integrins αIIb and β3 levels and enhanced in vitro and in vivo functional responses.