Published in
American Society of Hematology, Blood, 14(127), p. 1743-1751, 2016
DOI: 10.1182/blood-2015-07-661371
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- American Society of Hematology | PDF
- [europepmc.org] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Dicer1 mediated miRNA processing shapes the mRNA profile and function of murine platelets
Journal article published in 2016 by
Jesse W. Rowley,
Stéphane Chappaz 
,
Aurélie Corduan,
Mark M. W. Chong,
Robert Campbell,
Amanda Khoury,
Bhanu Kanth Manne,
Jeremy G. T. Wurtzel,
James V. Michael ,
Lawrence E. Goldfinger,
Michele M. Mumaw,
Marvin T. Nieman,
Benjamin Thomas Kile ,
Patrick Provost ,
Andrew S. Weyrich
,
Aurélie Corduan,
Mark M. W. Chong,
Robert Campbell,
Amanda Khoury,
Bhanu Kanth Manne,
Jeremy G. T. Wurtzel,
James V. Michael ,
Lawrence E. Goldfinger,
Michele M. Mumaw,
Marvin T. Nieman,
Benjamin Thomas Kile ,
Patrick Provost ,
Andrew S. Weyrich
This paper is made freely available by the publisher.
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Abstract
Key PointsDicer1 deletion in MKs alters platelet miRNA and mRNA profiles. Dicer1-deficient platelets display increased integrins αIIb and β3 levels and enhanced in vitro and in vivo functional responses.