Elsevier, Cell Stem Cell, 6(4), p. 470-471, 2009
DOI: 10.1016/j.stem.2009.05.006
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The role of multiple developmental signaling pathways in the regulation of hematopoiesis has been controversial. In this issue of Cell Stem Cell, two separate reports (Hofmann et al., 2009; Gao et al., 2009) examine whether the Hedgehog signaling pathway modulates normal adult hematopoietic stem cells and blood formation.