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American Society for Microbiology, Infection and Immunity, 2(73), p. 1204-1208, 2005

DOI: 10.1128/iai.73.2.1204-1208.2005

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Salmonella-Induced Filament Formation Is a Dynamic Phenotype Induced by Rapidly Replicating Salmonella enterica Serovar Typhimurium in Epithelial Cells

Journal article published in 2005 by Cheryl L. Birmingham, Xiuju Jiang, Maikke B. Ohlson, Samuel I. Miller, John H. Brumell
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Salmonella enterica serovar Typhimurium has the fascinating ability to form tubular structures known as Salmonella -induced filaments (Sifs) in host cells. Here, we show that the prevalence of the Sif phenotype in HeLa cells is affected by host cell density, growth, and the multiplicity of infection. Sif formation was observed in cells that displayed rapid intracellular bacterial replication and was found to be dynamic, being maximal 8 to 10 h postinfection and declining thereafter. The virulence factors SpvB and SseJ were found to negatively modulate Sif formation. Our findings demonstrate the complex and dynamic nature of the Sif phenotype.