S olid-state nanoparticles hold great promises for biomedical applications, notably thanks to the possibility to combine biological and inorganic materials with the prospect to develop innovative di-agnostic and therapeutic tools. Among them, nanoparticles such as quantum dots, 1,2 gold nanobeads, 3 or silicon beads 4 are used to label a biomolecule with high specificity, to track their fate in cultured cells and in organisms, or even to deliver bioactive molecules or drugs. Organic dyes and fluorophores are nowadays the most widely used fluorescent labels of biomole-cules. However, they photobleach rapidly under continuous illumination, 5 which makes their quantification and long-term follow-up difficult. Interestingly, semicon-ductor nanocrystals, or quantum dots (QDs), have a better stability and a lower photo-bleaching yield than organic dyes. They also offer the possibility of multicolor staining by size tuning. 2 On the other hand, such nanoparticles present major drawbacks, such as a potential cytotoxicity on long-term scale due to the chemical composi-tion of their core 6 or the intermittency of their photoluminescence (photoblinking), which makes an efficient tracking of indi-vidual nanoparticles difficult. 7