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National Academy of Sciences, Proceedings of the National Academy of Sciences, 9(112), p. 2729-2733, 2015

DOI: 10.1073/pnas.1418718112

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Structure of a left-handed DNA G-quadruplex

Journal article published in 2015 by Wan Jun Chung, Heddi Brahim, Emmanuelle Schmitt, Kah Wai Lim, Yves Mechulam, Anh Tuân Phan ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Significance DNA can adopt diverse structural conformations including duplexes, triplexes, and quadruplexes. Four-stranded structures known as G-quadruplexes have been implicated in cellular processes and found potential applications in therapeutics and nanotechnology. G-quadruplex structures are highly polymorphic, but so far, only right-handed helical forms have been observed. Here we present the NMR solution and X-ray crystal structures of an unprecedented left-handed DNA G-quadruplex, containing structural features that can be exploited as unique recognition elements.