Dendritic cells (DCs) mainly function to process/present antigens and thus initiate and shape the subsequent immune response. DCs are chiefly present within tissues in contact with the external environment and have a crucial role for maintaining immune homeostasis. Epithelial cells have been attracting considerable attention recently for they express a range of factors that influence the behavior of DCs. Organized by Euroscicon, this meeting focussed on integrating current knowledge and new paradigms surrounding the role of various DC subtypes and epithelial cells; their interaction with one another as well as with lymphocytes, microbial pathogens and commensal organisms. A wealth of experts currently researching this diverse field provided insight into these important interactions, their relevance to the medical setting and highlighted areas for future research.