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American Association for the Advancement of Science, Science Translational Medicine, 96(3), 2011

DOI: 10.1126/scitranslmed.3001512

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The Emergence of Genome-Based Drug Repositioning

Journal article published in 2011 by Yves A. Lussier ORCID, James L. Chen
This paper is available in a repository.
This paper is available in a repository.

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Abstract

In this issue of Science Translational Medicine, the Butte Research group provides a concrete example of how reinterpreting and comparing genome-wide metrics may allow us to effectively hypothesize which drugs from one disease indication can be used for another. Here we discuss the basis of this shift toward genomic computational integrative approaches that has precedence in scalar theories of biological information and is aptly warranted for exploitation in drug repurposing.