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Oxford University Press, Briefings in Functional Genomics, 1(10), p. 37-49, 2011

DOI: 10.1093/bfgp/elq038

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Chromatin structure of pluripotent stem cells and induced pluripotent stem cells

Journal article published in 2011 by Paul Delgado-Olguín ORCID, Félix Recillas-Targa
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Pluripotent embryonic stem (ES) cells are specialized cells with a dynamic chromatin structure, which is intimately connected with their pluripotency and physiology. In recent years somatic cells have been reprogrammed to a pluripotent state through over-expression of a defined set of transcription factors. These cells, known as induced pluripotent stem (iPS) cells, recapitulate ES cell properties and can be differentiated to apparently all cell lineages, making iPS cells a suitable replacement for ES cells in future regenerative medicine. Chromatin modifiers play a key function in establishing and maintaining pluripotency, therefore, elucidating the mechanisms controlling chromatin structure in both ES and iPS cells is of utmost importance to understanding their properties and harnessing their therapeutic potential. In this review, we discuss recent studies that provide a genome-wide view of the chromatin structure signature in ES cells and iPS cells and that highlight the central role of histone modifiers and chromatin remodelers in pluripotency maintenance and induction.