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Public Library of Science, PLoS ONE, 4(6), p. e18506, 2011

DOI: 10.1371/journal.pone.0018506

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Functional Energetics of CD4+-Cellular Immunity in Monoclonal Antibody-Associated Progressive Multifocal Leukoencephalopathy in Autoimmune Disorders

Journal article published in 2011 by Aiden Haghikia, Moritz Perrech, Bartosz Pula, Sabrina Ruhrmann, Anja Potthoff, Norbert H. Brockmeyer, Brockmeyer Nh, Susan Goelz, Heinz Wiendl ORCID, Hans Lindå, Tjalf Ziemssen, Sergio E. Baranzini, Tor-Bj Käll, Baranzini Se, Käll Tb and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Progressive multifocal leukoencephalopathy (PML) is an opportunistic central nervous system- (CNS-) infection that typically occurs in a subset of immunocompromised individuals. An increasing incidence of PML has recently been reported in patients receiving monoclonal antibody (mAb) therapy for the treatment of autoimmune diseases, particularly those treated with natalizumab, efalizumab and rituximab. Intracellular CD4+-ATP-concentration (iATP) functionally reflects cellular immunocompetence and inversely correlates with risk of infections during immunosuppressive therapy. We investigated whether iATP may assist in individualized risk stratification for opportunistic infections during mAb-treatment.