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American Society of Hematology, Blood, 11(126), p. 1379-1389, 2015

DOI: 10.1182/blood-2015-01-622811

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The polyphosphate-factor XII pathway drives coagulation in prostate cancer-associated thrombosis

Journal article published in 2015 by Katrin F. Nickel, Florian Langer, Linda Labberton, Tobias A. Fuchs, Göran Ronquist, Carsten Bokemeyer, Guido Sauter, Markus Graefen, Gunnar Ronquist, Nigel Mackman, Evi X. Stavrou ORCID, Thomas Renne
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Key Points Polyphosphate-activated coagulation factor XII drives prostate cancer-associated venous thrombosis. Targeting the polyphosphate/factor XII pathway reduces procoagulant activity in prostate cancer patient plasma and may permit safe anticoagulation.