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Elsevier, Steroids, 6(75), p. 457-465, 2010

DOI: 10.1016/j.steroids.2010.03.001

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Site-specific and dose-dependent effects of glucocorticoid receptor phosphorylation in yeast Saccharomyces cerevisiae

Journal article published in 2010 by Natasa Popovic, Sabera Ruzdijic, Dusan T. Kanazir, Ana Niciforovic, Miroslav Adzic, Elissavet Paraskevopoulou, Constantia Pantelidou ORCID, Marija Radojcic, Constantinos Demonacos, Ruzdijic S Kanazir DT Niciforovic A Radojcic M Demonacos C and Krstic-Demonacos M. Popovic N., Marija Krstic-Demonacos, Ruzdijic S Kanazir DT Niciforovi A Adzic M Paraskevopoulou E Pantelidou C Radojcic M Demonacos C Krstic-Demonacos M. Popovic N.
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This paper is available in a repository.

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Abstract

The glucocorticoid receptor (GR) signal transduction and transcriptional regulation are efficiently recapitulated when GR is expressed in Saccharomyces cerevisiae. In this report we demonstrate that the in vivo GR phosphorylation pattern, hormone dependency and interdependency of phosphorylation events were similar in yeast and mammalian cells. GR phosphorylation at S246 exhibited inhibitory effect on S224 and S232 phosphorylation, suggesting the conservation of molecular mechanisms that control this interdependence between yeast and mammalian cells.