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American Chemical Society, Organic Letters, 5(11), p. 1087-1090, 2009

DOI: 10.1021/ol802890b

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Motualevic Acids A–F, Antimicrobial Acids from the Sponge Siliquariaspongia sp.

Journal article published in 2009 by Jessica L. Keffer ORCID, Alberto Plaza, Carole A. Bewley
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Seven new antibacterials, motualevic acids A-F (1-6) and (4E)-(R)-antazirine (7), have been isolated from the marine sponge Siliquariaspongia sp. and their structures elucidated by spectroscopic methods. Motualevic acids A-D are the first glycyl conjugates of the omega-brominated lipid (E)-14,14-dibromotetradeca-2,13-dienoic acid, and motualevic acid F is the first long-chain 2H-azirine 2-carboxylic acid to be found in nature. Carboxylic acid-containing compounds 1 and 6 inhibit the growth of Staphylococcus aureus and methicillin-resistant S. aureus at 1.2-10.9 microg/mL.