Published in
Public Library of Science, PLoS ONE, 6(5), p. e10943, 2010
DOI: 10.1371/journal.pone.0010943
Links
- Public Library of Science
- ORCID
- [www.ncbi.nlm.nih.gov] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
Tools
Lowering β-Amyloid Levels Rescues Learning and Memory in a Down Syndrome Mouse Model
,
Yi Nong,
Jacqueline Blundell,
Lili Wong,
Karen Duff,
Marc Flajolet,
Paul Greengard
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Abstract
beta-amyloid levels are elevated in Down syndrome (DS) patients throughout life and are believed to cause Alzheimer's disease (AD) in adult members of this population. However, it is not known if beta-amyloid contributes to intellectual disability in younger individuals. We used a gamma-secretase inhibitor to lower beta-amyloid levels in young mice that model DS. This treatment corrected learning deficits characteristic of these mice, suggesting that beta-amyloid-lowering therapies might improve cognitive function in young DS patients.