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Oxford University Press, Open Forum Infectious Diseases, 4(2), 2015

DOI: 10.1093/ofid/ofv144

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Aviremia 10 Years Postdiscontinuation of Antiretroviral Therapy Initiated During Primary Human Immunodeficiency Virus-1 Infection and Association With Gag-Specific T-Cell Responses

Journal article published in 2015 by Sabine Kinloch-De Loes, Lucy Dorrell, Hongbing Yang, Gareth A. D. Hardy, Sabine Yerly, Cristina Cellerai, Linos Vandekerckhove, Ward De Spielgelaere ORCID, Eva Malatinkova, Willie Wee Lee Koh, Margaret A. Johnson
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Combination antiretroviral therapy during primary human immunodeficiency virus-1 infection may enable long-term drug-free virological control in rare individuals. We describe a female who maintained aviremia and a normal CD4+/CD8+ T cell ratio for 10 years after stopping therapy, despite a persistent viral reservoir. Cellular immune responses may have contributed to this outcome.