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Georg Thieme Verlag, Hormone and Metabolic Research, 13(47), p. 959-966

DOI: 10.1055/s-0035-1565089

Elsevier, Molecular and Cellular Endocrinology

DOI: 10.1016/j.mce.2015.04.022

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Subtype Diagnosis of Primary Aldosteronism: Approach to Different Clinical Scenarios

Journal article published in 2015 by J. Burrello ORCID, S. Monticone ORCID, M. Tetti, D. Rossato, K. Versace, I. Castellano, T. A. Williams, F. Veglio, P. Mulatero
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This paper is available in a repository.

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Abstract

AbstractIdentification and management of patients with primary aldosteronism are of utmost importance because it is a frequent cause of endocrine hypertension, and affected patients display an increase of cardio- and cerebro-vascular events, compared to essential hypertensives. Distinction of primary aldosteronism subtypes is of particular relevance to allocate the patients to the appropriate treatment, represented by mineralocorticoid receptor antagonists for bilateral forms and unilateral adrenalectomy for patients with unilateral aldosterone secretion. Subtype differentiation of confirmed hyperaldosteronism comprises adrenal CT scanning and adrenal venous sampling. In this review, we will discuss different clinical scenarios where execution, interpretation of adrenal vein sampling and subsequent patient management might be challenging, providing the clinician with useful information to help the interpretation of controversial procedures.