Published in
Elsevier, Bioorganic and Medicinal Chemistry Letters, 14(7), p. 1931-1936
DOI: 10.1016/s0960-894x(97)00340-5
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1-Arylsulfonyl-3-(α-hydroxybenzyl)-1H-pyrroles, a novel class of anti-HIV-1 reverse transcriptase inhibitors
Journal article published in 1997 by
Marino Artico,
R. Di Santo 
,
Roberto Di Santo,
Roberta Costi ,
Silvio Massa,
Franca Scintu,
Anna Giulia Loi,
Antonella De Montis,
Paolo La Colla
,
Roberto Di Santo,
Roberta Costi ,
Silvio Massa,
Franca Scintu,
Anna Giulia Loi,
Antonella De Montis,
Paolo La Colla
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Abstract
Reaction of benzenesulfonyl chlorides with 1H-pyrrole afforded the related 1-benzenesulfonyl pyrroles, which were transformed into the corresponding 3-aroyl derivatives by Friedel-Crafts condensation. Reduction of the ketone group led to 1-arylsulfonyl-3-(α-hydroxybenzyl)-1H-pyrroles. When assayed on MT-4 cells some carbinol derivatives were found to be active against HIV-1 at low micromolar concentrations.