FDG PET and MRI in Logopenic Primary Progressive Aphasia versus Dementia of the Alzheimer’s Type

Madhavan, Ajay; Whitwell, Jennifer L.; Weigand, Stephen D.; Duffy, Joseph R.; Strand, Edythe A.; Machulda, Mary M.; Tosakulwong, Nirubol; Senjem, Matthew L.; Gunter, Jeffrey L.; Lowe, Val J.; Petersen, Ronald C.; Jack, Clifford R.; Josephs, Keith A.

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Public Library of Science, PLoS ONE, 4(8), p. e62471, 2013

DOI: 10.1371/journal.pone.0062471

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FDG PET and MRI in Logopenic Primary Progressive Aphasia versus Dementia of the Alzheimer’s Type

Journal article published in 2013 by Ajay Madhavan, Jennifer L. Whitwell, Stephen D. Weigand, Joseph R. Duffy, Edythe A. Strand, Mary M. Machulda, Nirubol Tosakulwong, Matthew L. Senjem

, Jeffrey L. Gunter, Val J. Lowe, Ronald C. Petersen, Clifford R. Jack, Keith A. Josephs

This paper is made freely available by the publisher.

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Abstract

The logopenic variant of primary progressive aphasia is an atypical clinical variant of Alzheimer’s disease which is typically characterized by left temporoparietal atrophy on magnetic resonance imaging and hypometabolism on F-18 fluorodeoxyglucose positron emission tomography. We aimed to characterize and compare patterns of atrophy and hypometabolism in logopenic primary progressive aphasia, and determine which brain regions and imaging modality best differentiates logopenic primary progressive aphasia from typical dementia of the Alzheimer’s type.

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FDG PET and MRI in Logopenic Primary Progressive Aphasia versus Dementia of the Alzheimer’s Type

Abstract