Defining the role of common variation in the genomic and biological architecture of adult human height.

Ärnl, Johan; Ärnlöv, Johan; de Andrade, Mariza M.; de Boer, Rudolf A. Ra; van der Klauw, Melanie M. Mm; den Ruijter Hester, M.; Zonzin, Pietro P.; Ziegler, Andreas A.; de Bakker Paul, I. W.; Ziegler, Andreas A; Zheng, Wei W.; van Duijn Cornelia, M.; Zhang, Weihua W.; Yee, Jean J.; Yee, Jean J; Young, Alicia A.; Wood, Andrew R. Ar; Wang, Zhaoming Z; Wang, Zhaoming Z.; Schumacher, Fredrick R.; Zhao, Jing Hua JH; Schumacher, Fredrick R. Fr; Wilkens, Lynne R.; Wang, Zhaoming; Wilkens, Lynne R. Lr; Ritchie, Marylyn M.; Starren, Justin J.; Wang, Z.; Rasmussen, Luke L.; Waudby, Carol C.; Reeser, Jonathan J.; Pers, Tune H. Th; Wilke, Russell A. Ra; Smith, Maureen E. Me; Wolf, Wendy A. Wa; Chu, Audrey Y. Ay; Thompson, William K. Wk; Randall, Joshua C. Jc; Esko, Tonu Tõnu; Wang, Zm; Scherag, André Andre; Yang, Jian J.; Savova, Guergana G.; Wu, Joel J.; Vinkhuyzen, Anna Ae E. Aa; Wolfgang, Hoffmannm; Westra, Harm-Jan Hj; Buchkovich, Martin L. Ml; Spangler, Leslie L.; Trinidad, Susan Brown SB; Croteau-Chonka, Damien C. Dc; Winkler, Thomas W. Tw; Roden, Dan M. Dm; Day, Felix R. Fr; Schildcrout, Jonathan S. Js; Workalemahu, Tsegaselassie T.; Xu, Hua H.; Ramirez, Andrea Havens AH; Pulley, Jill J.; Rosmalen, Judith G. M. Jg; Vedantam, Sailaja S.; Slaets, Joris P. Jp; Jackson, Anne U. Au; Wolffenbuttel, Bruce H. R. Bh; Duan, Yanan Y.; Wijmenga, Cisca C.; Voight, Benjamin F. Bf; Purcell, Shaun S.; Lo, Ken Sin KS; Ritchie, Marylyn M; Reilly, Muredach P.; van der Laan, Sander W. Sw; Locke, Adam E. Ae; Fall, Tove T.; Rader, Daniel J. Dj; van Setten, Jessica J.; Spertus, John A. Ja; Stoll, Monika M.; Mägi, Reedik R.; Siscovick, David S. Ds; Fehrmann, Rudolf R.; Shin, Jianxin; Yengo, Loïc Loïc; Mihailov, Evelin E.; Schwartz, Stephen M. Sm; Zhang, Weihua; Tubaro, Marco M.; Ribichini, Flavio F.; Ferreira, Teresa T.; Porcu, Eleonora Evelin; Rossi, Marco M.; Subirana, Isaac I.; Ramos, Rafael R.; Sala, Joan J.; Williams, Gordon G.; Voight, Benjamin F. B.; Karjalainen, Juha J.; Schunkert, I. Heribert I; Spreafico, Marta M.; Surti, Aarti A.; Thompson, John R.; Schwartz, Stephen M Sm; Absher, Devin D.; Siscovick, David S Ds; Albrecht, Eva E.; Schumacher, Fredrick Fr; Wright, Benjamin J. Bj; Anderson, Denise D.; Stark, Klaus K.; Schreiber, Stefan S.; Baron, Jeffrey J.; Beekman, Marian M.; Purcell, Shaun S; Voight, Benjamin F Bf; Prokopenko, Inga I.; Demirkan, Ayse Ayşe; Gustafsson, Stefan S.; Ehret, Georg Benedikt Gb; Ried, Janina S. Js; Wilkens, Lynne Lr; Feenstra, Bjarke B.; Ripke, Stephan S.; Van Der Laan, Sander W.; Feitosa, Mary F.; Scholz, Michael M.; de Groot, Lisette C. P. G. M. Lc; Fischer, Krista K.; Shungin, Dmitry D.; Subirana, Isaac I; Van Vliet-Ostaptchouk, Jv; Fraser, Ross M. Rm; Stancáková, Alena A.; Wilensky, Robert R.; Goel, Anuj A.; Van Vliet-Ostaptchouk, Jana V. Jv; Setten, J. van; Gong, Jian J.; Strawbridge, Rona J. Rj; Qasim, Atif A.; Kanoni, Stavroula S.; Vliet-Ostaptchouk, J. V. Van; Sung, Yun Ju YJ; Kleber, Marcus E. Me; Waksman, Ron R.; Tanaka, Toshiko T.; Kristiansson, Kati K.; Satler, Lowell L.; Lim, Unhee U.; Walker, Max C. Mc; Lotay, Vaneet; Waterworth, Dawn M. Dm; Teumer, Alexander A.; Lui, Julian C. Jc; Scheffold, Thomas T.; Mangino, Massimo M.; Estrada, Karol K.; Trompet, Stella S.; The, MIGen Consortium; The, Page Consortium; Medina-Gomez, Carolina C.; Warwick Daw, E.; Nalls, Michael A.; Nyholt, Dale R. Dr; Xie, Changchun C.; Palmer, Cameron D. Cd; Tönjes, Anke; Pasko, Dorota D.; Pechlivanis, Sonali S.; Toenjes, Anke; Siscovick, David D.; Rader, Daniel J Dj; Luan, Jian'An Jian’an; Williams, Rasheeda R.; Spertus, John A Ja; Stark, Klaus K; Ar, Wood; Taylor, Kira K.; Schreiber, Stefan S; Quibrera, Miguel M.; Afzal, Uzma U.; Volzke, Henry; Voelzke, Henry; Arscott, Gillian M. Gm; Thornton-Wells, Tricia T.; Kutalik, Zoltán Zoltán; Bandinelli, Stefania S.; Restrepo, Nicole N.; Barrett, Amy A.; Umans, Jason J.; Bellis, Claire C.; Bennett, Amanda J. Aj; Wilson, Sarah S.; Berne, Christian C.; Spencer, Kylee K.; Blüher, Matthias M.; Bolton, Jennifer L. Jl; Wang, Hansong H.; Böttcher, Yvonne Y.; Shohet, Ralph R.; Boyd, Heather A. Ha; Stram, Daniel D.; Tiirikainen, Maarit M.; Bruinenberg, Marcel M.; Wu, Chunyuan C.; Buckley, Brendan M. Bm; Amin, Najaf N.; Rosse, Stephanie S.; Buyske, Steve Steven; Caspersen, Ida H. Ih; Chines, Peter S. Ps; Clarke, Robert R.; Claudi-Boehm, Simone S.; Cooper, Matthew M.; De Jong, Pim A. Pa; A. E., Justice; Deelen, Joris J.; Delgado, Graciela G.; Denny, Josh C. Jc; van Dijk, Suzanne S.; Dhonukshe-Rutten, Rosalie R.; Justice, Anne E.; van Schoor, Natasja M. Nm; Dimitriou, Maria M.; van der Velde, Nathalie; Doney, Alex Sf F. As; Price, Jackie F. Jf; van Heemst, Diana D.; Leach, Im M.; Dörr, Marcus M.; Daw, Ew Warwick EW; van Oort, Floor Va A. Fv; Eklund, Niina N.; Eury, Elodie E.; Folkersen, Lasse L.; Garcia, Melissa E. Me; Geller, Frank F.; Giedraitis, Vilmantas; Go, Alan S. As; Grallert, Harald H.; Grammer, Tanja B. Tb; Zhang, Qunyuan Qy; Gräßler, Jürgen J.; Th, Pers; Grönberg, Henrik H.; Groves, Christopher J. Cj; Haessler, Jeff Jeffrey; Hall, Per; E., Anne; Haller, Toomas T.; Hallmans, Goran Göran; Peissig, Peggy P.; Hannemann, Anke A.; Hartman, Catharina A. Ca; Hassinen, Maija M.; Hayward, Caroline C.; Mateo Leach, Irene I.; Schumacher, Fr R.; de Faire, Ulf U.; Heard-Costa, Nancy L. Nl; den Ruijter, Hester M. Hm; Kho, Abel N.; Helmer, Quinta Q.; Hemani, Gibran G.; Henders, Anjali K. Ak; Hillege, Hans L. Hl; Johansson, Å.; Hlatky, Mark A.; Hoffmann, Wolfgang W.; Hoffmann, Per P.; Postma, Dirkje S. Ds; Holmen, Oddgeir O.; De Groot, Lisette C. P. G. M.; Houwing-Duistermaat, Jeanine J. Jj; Van Dijk, Suzanne; Illig, Thomas T.; Isaacs, Aaron A.; Van Schoor, Natasja M.; James, Alan L. Al; Jeff, Janina Jarina; Johansen, Berit Bent; Van Der Velde, N.; Jolley, Jennifer J.; Van Heemst, Diana; Van Oort, Floor V. A.; Juliusdottir, Thorhildur T.; Junttila, Juhani J.; Peltonen, Leena L.; Kinnunen, Leena L.; Peyvandi, Flora F.; Klopp, Norman N.; Kocher, Thomas T.; Kratzer, Wolfgang W.; Wilkens, Lr R.; Lichtner, Peter P.; Piazza, Alberto A.; Lind, Lars L.; Arnlov, Johan; Lindström, Jaana J.; Lobbens, Stéphane Stéphane; Rayner, Nigel W. Nw; Johansson, Åsa; Lorentzon, Mattias Matthias; Renstrom, Frida F.; Lu, Yingchang Yc; Lyssenko, Valeriya; Robertson, Neil R. Nr; Magnusson, Patrik Ke E. Pk; Rose, Lynda M. Lm; Peltonen, Leena L; Mahajan, Anubha A.; Roussel, Ronan R.; Maillard, Marc M.; Preuss, Michael M.; McArdle, Wendy L. Wl; Sanna, Serena S.; McKenzie, Colin A. Ca; Scharnagl, Hubert H.; McLachlan, Stela S.; Scholtens, Salome S.; McLaren, Paul J. Pj; Menni, Cristina C.; Schunkert, Heribert H.; Merger, Sigrun S.; Pichard, Augusto D. Ad; Scott, Robert A. Ra; Milani, Lili L.; Moayyeri, Alireza A.; Sehmi, Joban J.; Monda, Keri L. Kl; Seufferlein, Thomas T.; Morken, Mario A.; Shi, Jianxin J.; Müller, Gabriele G.; Müller-Nurasyid, Martina M.; Silventoinen, Karri K.; Musk, Arthur W. Aw; Smit, Johannes H. Jh; Narisu, Narisu N.; Smith, Albert Vernon AV; Nauck, Matthias M.; Preuss, Michael M; Smolonska, Joanna J.; Nolte, Ilja M. Im; Nöthen, Markus M. Mm; Stanton, Alice V. Av; Perusse, Louis; Oozageer, Laticia L.; Stirrups, Kathleen K.; Pilz, Stefan S.; Pérusse, Louis; Stott, David J. Dj; Person, Sharina S.; Stringham, Heather M. Hm; Sundström, Johan J.; Swertz, Morris A.; Syvänen, Ann-Christine Ac; de Bakker, Paul Iw W. Pi; Pendergrass, Sarah S.; Tayo, Bamidele O. Bo; Thorleifsson, Gudmar G.; Prentice, Ross R.; Tyrer, Jonathan P. Jp; Chun, Audrey Y.; Ae, Anne E.; Johansson, Åsa Å; Buyske, Steven S.; Mägi, Reedik; Haessler, Jeffrey J.; Hall, Per P.; Kho, Abel N. An; Vermeulen, Sita H. Sh; Maegi, Reedik; Ae, Justice; Verweij, Niek N.; Magi, Reedik; Wouter Jukema, J.; Ju Sung, Yun; Vonk, Judith M. Jm; McCarty, Catherine A. Ca; Berg, Richard R.; Waite, Lindsay L. Ll; Linneman, James J.; Böttcher, Yvonne; Waldenberger, Melanie M.; Miller, Aaron A.; Wennauer, Roman R.; Choudary, Vidhu; Chen, Lin L.; Willenborg, Christina C.; Kitchner, Terrie T.; Wilsgaard, Tom T.; Fost, Norman N.; Chisholm, Rex L. Rl; Wojczynski, Mary K. Mk; Avila, Pedro C. Pc; Greenland, Philip P.; Wong, Andrew A.; Arnl, Johan J.; Kibbe, Warren A. Wa; Wright, Alan F. Af; Ay, Chu; Lemke, Amy A. Aa; Lowe, William L. Wl; Pacheco, Jennifer A. Ja; Humowiecki, Joel J.; Grönberg, Henrik; Chute, Christopher C.; Law, May M.; van der Harst, Pim P.; Kullo, Iftikar I.; Arnloev, Johan; Koenig, Barbara B.; Bielinski, Suzette S.; Pathak, Jyotishman J.; Zanen, Pieter P.; Henriksen, Joan J.; Blueher, Matthias; Ding, Keyue K.; Arveiler, Dominique D.; Boettcher, Yvonne; Hart, Lacey L.; Bakker, Stephan Jl L. Sj; Palbicki, Jeremy J.; Beilby, John J.; Larson, Eric B. Eb; Newton, Katherine K.; Bergman, Richard N.; Ludman, Evette E.; Bergmann, Sven S.; Hart, Gene G.; Carrell, David D.; Biffar, Reiner R.; van Duijn, Cornelia M. Cm; Jarvik, Gail G.; Blangero, John J.; Crane, Paul P.; Boomsma, Dorret I. Di; Burke, Wylie W.; Bornstein, Stefan R.; Fullerton, Stephanie Malia SM; Carlson, Chris C.; Bovet, Pascal P.; Hutchinson, Fred F.; McDavid, Andrew A.; Brambilla, Paolo P.; Dörr, Marcus; Brown, Morris J. Mj; Doerr, Marcus; Clayton, Ellen E.; Campbell, Harry H.; Haines, Jonathan L. Jl; Caulfield, Mark J. Mj; Chakravarti, Aravinda A.; Masys, Daniel R. Dr; Churchill, Larry R. Lr; Collins, Rory R.; Cornfield, Daniel D.; Collins, Francis S. Fs; Gräßler, Jürgen; Crawford, Dana C. Dc; Graessler, Juergen; Danesh, John J.; Groenberg, Henrik; Van Der Harst, Pim; Crawford, Dana D.; Erbel, Raimund R.; Mckenzie, Colin A.; Erdmann, Jeanette J.; Gronberg, Henrik; Eriksson, Johan G. Jg; Cupples, La Adrienne LA; Farrall, Martin M.; Ferrannini, Ele E.; Darbar, Dawood D.; Ferrières, Jean J.; Ford, Ian I.; Mclachlan, Stela; De Faire, Ulf; Forouhi, Nita G. Ng; Forrester, Terrence T.; Malin, Bradley A.; Den Ruijter, Hm M.; Gansevoort, Ron T. Rt; Gejman, Pablo V. Pv; Denny, Joshua C. Jc; Gieger, Christian C.; Bottcher, Yvonne; Golay, Alain A.; Gottesman, Omri O.; Müller, Gabriele; Gudnason, Vilmundur; Gyllensten, Ulf U.; Müller-Nurasyid, Martina; Haas, David W. Dw; Basford, Melissa M.; Van Duijn, Cm M.; Hall, Alistair S. As; Alizadeh, Behrooz Z. B.; Harris, Tamara B. Tb; Hattersley, Andrew T. At; Boezen, H. Marike HM; Heath, Andrew C. Ac; Hengstenberg, Christian C.; Hicks, Andrew A. Aa; Navis, Gerjan G.; Pagege, Consortium; Hindorff, Lucia A. La; Ormel, Johan J.; Hingorani, Aroon D. Ad; Hofman, Albert A.; Kho, An N.; Lindstroem, Jaana; Humphries, Steve E. Se; Kathiresan, Sekar S.; Hunt, Steven C. Sc; Hypponen, Elina E.; Ardissino, Diego D.; Hovingh, Gk Kees GK; Jacobs, Kevin B. Kb; Tm, Frayling; Musunuru, Kiran K.; Jarvelin, Marjo-Riitta Mr; Qi, Lu L.; Jousilahti, Pekka P.; Mannucci, Pier M. Pm; Jula, Antti M. Am; Raitakari, Olli T. Ot; Anand, Sonia S.; Rankinen, Tuomo T.; Kaprio, Jaakko J.; Kastelein, John Jp P. Jj; Engert, James C. Jc; Rao, Dc C. Dc; Kayser, Manfred M.; Mueller, Gabriele; Rice, Treva K. Tk; Kee, Frank F.; Keinanen-Kiukaanniemi, Sirkka M. Sm; Ritchie, Marylyn D.; Morgan, Thomas T.; Rudan, Igor I.; Kiemeney, Lambertus A. La; Mueller-Nurasyid, Martina; Kooner, Jaspal S. Js; Kho, Abel An; Salomaa, Veikko; Kooperberg, Charles C.; Girelli, Domenico D.; Koskinen, Seppo S.; Samani, Nilesh J. Nj; Noethen, Markus M.; Kovacs, Peter P.; Saramies, Jouko J.; McKeown, Pascal P. Pp; Kraja, Aldi T. At; Sarzynski, Mark A.; Adrienne Cupples, L.; Schwarz, Peter Eh H. Pe; Patterson, Chris C. Cc; Kumari, Meena M.; Kuusisto, Johanna J.; Muller, Gabriele; Sebert, Sylvain S.; Lakka, Timo A. Ta; Nothen, Markus Mm; Sever, Peter P.; Study, LifeLines Cohort; Langenberg, Claudia C.; Shuldiner, Alan R. Ar; Muller-Nurasyid, Martina; Sinisalo, Juha J.; Lehtimäki, Terho T.; O'Donnell, Christopher J. Cj; Steinthorsdottir, Valgerdur; Lupoli, Sara S.; Elosua, Roberto R.; Madden, Pamela Af F. Pa; Melander, Olle O.; Stolk, Ronald P. Rp; Männistö, Satu S.; Merlini, Pier Angelica PA; Le Marchand, Loic L.; Tardif, Jean-Claude Jc; Manunta, Paolo P.; Altshuler, David D.; Tönjes, Anke A.; Marette, André Andre; Tremblay, Angelo A.; Matise, Tara C. Tc; Berzuini, Carlo C.; Tremoli, Elena E.; McKnight, Barbara B.; H. Vermeulen, Sita; Virtamo, Jarmo J.; Ferrario, Maurizio M.; Meitinger, Thomas T.; Vohl, Marie-Claude Mc; Bernardinelli, Luisa L.; Moll, Frans L. Fl; Montgomery, Grant W. Gw; Celli, Patrizia P.; Morris, Andrew D. Ad; Marziliano, Nicola N.; Morris, Andrew P. Ap; Fetiveau, Raffaela R.; Murray, Jeffrey C. Jc; Casari, Giorgio G.; Nelis, Mari M.; Kees Hovingh, G.; Ohlsson, Claes C.; Galli, Michele M.; Oldehinkel, Albertine J. Aj; Bernardi, Francesco F.; Ong, Ken K. Kk; Slagboom, Pe Eline PE; Ouwehand, Willem H. Wh; Friedlander, Yechiel Y.; Consortium, Electronic Medical Records and Genomics (eMEMERGEGE); Pasterkamp, Gerard G.; Lucas, Gavin G.; Peters, Annette A.; Marrugat, Jaume J.; Pramstaller, Peter P. Pp; Meigs, James B. Jb; Nathan, David M. Dm; Havulinna, Aki S. As; Duga, Stefano S.; MacRae, Calum A. Ca; Wichmann, He-Erich He; Berglund, Goran G.; Asselta, Rosanna R.; Korn, Joshua M. Jm; Marchand, Loic Le; Nemesh, James J.; Daly, Mark J. Mj; Price, Jackie F.; Ardissino, Diego D; Gianniny, Lauren L.; Guiducci, Candace C.; McCarroll, Steven A. Sa; Parkin, Melissa M.; Burtt, Noel N.; Gabriel, Stacey B. Sb; Mirel, Daniel D.; Braund, Peter S. Ps; Loic, Le Marchandm; Records, Electronic Medical; Mannucci, Pier M Pm; Elosua, Roberto R; Balmforth, Anthony J. Aj; Ball, Stephen G. Sg; Pérusse, Louis L.; Kathiresan, Sekar S; Linsel-Nitschke, Patrick P.; Amouyel, Philippe P.; Lieb, Wolfgang W.; Ml, Buchkovich; O'Donnell, Christopher J Cj; Asselbergs, Folkert W. Fw; Fischer, Marcus M.; Melander, Olle O; Assimes, Themistocles L. Tl; Quertermous, Thomas T.; König, Inke R. Ir; Bochud, Murielle Murille; Rauramaa, Rainer R.; Grosshennig, Anika A.; Boehm, Bernhard O. Bo; Hayes, Mg Geoffrey MG; Reinmaa, Eva E.; Boerwinkle, Eric E.; Ks, Lo; Ridker, Paul M. Pm; Musunuru, Kiran K; Bottinger, Erwin P. Ep; Goodall, Alison A.; Bouchard, Claude C.; Rivadeneira, Fernando F.; Ouwehand, Willem W.; Cauchi, Stéphane Stephane; Männistö, Satu; Rotter, Jerome I. Ji; Chambers, John C. Jc; Cambien, Francois F.; Saaristo, Timo E. Te; Chanock, Stephen J. Sj; Saleheen, Danish D.; Mcknight, Barbara; Ae, Locke; Cooper, Richard S. Rs; Schlessinger, David D.; Lucas, Gavin G; Dedoussis, George G.; Chen, Zhen Z.; Ferrucci, Luigi L.; Snieder, Harold H.; Li, Mingyao M.; Spector, Tim D. Td; Mannisto, Satu; Franks, Paul W. Pw; Strauch, Konstantin K.; Matthai, William W.; Froguel, Philippe P.; Stumvoll, Michael M.; De Bakker, Piw I. W.; Laan, S. W. van der; Groop, Leif C. Lc; Tuomilehto, Jaakko J.; Haiman, Christopher A. Ca; Uusitupa, Matti M.; Dc, Croteau Chonka; Hakonarson, Hakon H. Hh; Hamsten, Anders A.; Völzke, Henry H.; Kent, Kenneth M. Km; Devaney, Joe J.; Hui, Jennie J.; Walker, Mark M.; Burnett, Mary-Susan; Hunter, David J. Dj; Wareham, Nicholas J. Nj; Watkins, Hugh H.; Hveem, Kristian K.; Knouff, Christopher W. Cw; Lindsay, Joseph M. Jm; Kaplan, Robert C. Rc; Wilson, James F. Jf; Hayes, Mg Geoff M.; Kivimaki, Mika M.; Jukema, Jw Wouter JW; König, Inke R. I.; Kuh, Diana D.; Mooser, Vincent; Laakso, Markku M.; Liu, Yongmei Ym; Medical, Records The Electronic; Martin, Nicholas G. Ng; Genomics, Consortium; Speliotes, Elizabeth K. Ek; März, Winfried W.; Epstein, Stephen E. Se; Melbye, Mads M.; Thorsteinsdottir, Unnur U.; Cohort, Study The LifeLines; Consortium, MIGen; Moebus, Susanne S.; Hólm, Hilma H.; Munroe, Patricia B. Pb; Do, Ron R.; Njølstad, Inger I.; Geoffrey Hayes, M.; Oostra, Ben A.; Berger, Klaus K.; Palmer, Colin Na A. Cn; Strachan, David P. Dp; Pedersen, Nancy L. Nl; ..,; Perola, Markus M.; Higashio, Julia J.; Peters, Ulrike U.; Matise, Tara T.; Powell, Joseph E. Je; Au, Jackson; Power, Chris C.; Nato, Andrew A.; Hindorff, Lucia L.; Stefansson, Kari K.; Linsel-Nitschke, Patrick P; Uitterlinden, André G. Ag; Manolio, Teri T.; Huge, Andreas A.; Lieb, Wolfgang W; Fr, Day; Heiss, Gerardo G.; Fischer, Marcus M; Willer, Cristen J. Cj; Ambite, Jose Luis JL; Patterson, Chris C Cc; McKeown, Pascal P Pp; Franceschini, Nora N.; Grosshennig, Anika A; Deelman, Ewa E.; März, Winfried; Eline Slagboom, P.; Martinelli, Nicola N.; Weedon, Michael N. Mn; Corrocher, Roberto R.; Marz, Winfried; Olivieri, Oliviero O.; Avery, Christy C.; Engert, James C Jc; Maerz, Winfried; Lin, Danyu D.; Anand, Sonia S; Graff, Misa M.; Cochran, Barbara B.; MacCluer, Jean J.; Cole, Shelley S.; Visscher, Peter M. Pm; Pankow, James J.; Altshuler, David D; Gross, Myron M.; Erich Wichmann, H.; Jenny, Nancy N.; Fornage, Myriam M.; Arnold, Alice A.; Durda, Peter P.; Patsy, Bruce B.; Kao, Linda L.; Deloukas, Panos P.; Murdock, Deborah D.; Haines, Jonathan J.; Heid, Iris M. Im; Glenn, Kim K.; Lindgren, Cecilia M. Cm; Buzkova, Petra P.; Mohlke, Karen L. Kl; Bush, William S. Ws; Boston, Jonathan J.; Goodloe, Robert R.; Malinowski, Jennifer J.; Barroso, Inês Inês; Crawford, Dana D; Fox, Caroline S. Cs; Oetjens, Matthew M.; North, Kari E. Ke; Fowke, Jay J.; Jong, P. A. de; Beckmann, Jacques S. Js; Kolonel, Laurence L.; Berndt, Sonja I. Si; Cheng, Iona I.; Boehnke, Michael M.; Park, Lani L.; Borecki, Ingrid B. Ib; Dumitrescu, Logan L.; McCarthy, Mark I. Mi; Metspalu, Andres A.; Brown-Gentry, Kristin K.; Haiman, Christopher C.; Mitchell, Sabrina L. Sl; Henderson, Brian B.; Monroe, Kristine K.; Franke, Lude L.; Anderson, Garnet G.; LaCroix, Andrea A.; Carlson, Chris C; Price, Alkes L. Al; O’connell, Jeffrey R.; Lettre, Guillaume G.; Carty, Cara C.; Loos, Ruth Jf F. Rj; Kocarnik, Jonathan J.; Lin, Yi Y.; Elect Med Records &amp; Genom eMERGE, C.; Ingelsson, Erik E.; Jackson, Rebecca R.; O'Connell, Jeffrey R.; &amp;amp, Elect Med Records; Abecasis, Goncalo R. Gr; Duggan, David D.; Chasman, Daniel I. Di; Genom eMERGE, C.; Goddard, Michael E. Me; Page, Consortium; Ja, Spertus; Kuller, Lew L.; Hirschhorn, Joel N. Jn; Frayling, Timothy M. Tm; Other, And; Others,

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@article{Ärnl2014,
  abstract = {Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated approximately 2,000, approximately 3,700 and approximately 9,500 SNPs explained approximately 21%, approximately 24% and approximately 29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/beta-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.},
  author = {Ärnl, Johan and Ärnlöv, Johan and de Andrade, Mariza M. and de Boer, Rudolf A. Ra and van der Klauw, Melanie M. Mm and den Ruijter Hester, M. and Zonzin, Pietro P. and Ziegler, Andreas A. and de Bakker Paul, I. W. and Ziegler, Andreas A and Zheng, Wei W. and van Duijn Cornelia, M. and Zhang, Weihua W. and Yee, Jean J. and Yee, Jean J and Young, Alicia A. and Wood, Andrew R. Ar and Wang, Zhaoming Z and Wang, Zhaoming Z. and Schumacher, Fredrick R. and Zhao, Jing Hua JH and Schumacher, Fredrick R. Fr and Wilkens, Lynne R. and Wang, Zhaoming and Wilkens, Lynne R. Lr and Ritchie, Marylyn M. and Starren, Justin J. and Wang, Z. and Rasmussen, Luke L. and Waudby, Carol C. and Reeser, Jonathan J. and Pers, Tune H. Th and Wilke, Russell A. Ra and Smith, Maureen E. Me and Wolf, Wendy A. Wa and Chu, Audrey Y. Ay and Thompson, William K. Wk and Randall, Joshua C. Jc and Esko, Tonu Tõnu and Wang, Zm and Scherag, André Andre and Yang, Jian J. and Savova, Guergana G. and Wu, Joel J. and Vinkhuyzen, Anna Ae E. Aa and Wolfgang, Hoffmannm and Westra, Harm-Jan Hj and Buchkovich, Martin L. Ml and Spangler, Leslie L. and Trinidad, Susan Brown SB and Croteau-Chonka, Damien C. Dc and Winkler, Thomas W. Tw and Roden, Dan M. Dm and Day, Felix R. Fr and Schildcrout, Jonathan S. Js and Workalemahu, Tsegaselassie T. and Xu, Hua H. and Ramirez, Andrea Havens AH and Pulley, Jill J. and Rosmalen, Judith G. M. Jg and Vedantam, Sailaja S. and Slaets, Joris P. Jp and Jackson, Anne U. Au and Wolffenbuttel, Bruce H. R. Bh and Duan, Yanan Y. and Wijmenga, Cisca C. and Voight, Benjamin F. Bf and Purcell, Shaun S. and Lo, Ken Sin KS and Ritchie, Marylyn M and Reilly, Muredach P. and van der Laan, Sander W. Sw and Locke, Adam E. Ae and Fall, Tove T. and Rader, Daniel J. Dj and van Setten, Jessica J. and Spertus, John A. Ja and Stoll, Monika M. and Mägi, Reedik R. and Siscovick, David S. Ds and Fehrmann, Rudolf R. and Shin, Jianxin and Yengo, Loïc Loïc and Mihailov, Evelin E. and Schwartz, Stephen M. Sm and Zhang, Weihua and Tubaro, Marco M. and Ribichini, Flavio F. and Ferreira, Teresa T. and Porcu, Eleonora Evelin and Rossi, Marco M. and Subirana, Isaac I. and Ramos, Rafael R. and Sala, Joan J. and Williams, Gordon G. and Voight, Benjamin F. B. and Karjalainen, Juha J. and Schunkert, I. Heribert I and Spreafico, Marta M. and Surti, Aarti A. and Thompson, John R. and Schwartz, Stephen M Sm and Absher, Devin D. and Siscovick, David S Ds and Albrecht, Eva E. and Schumacher, Fredrick Fr and Wright, Benjamin J. Bj and Anderson, Denise D. and Stark, Klaus K. and Schreiber, Stefan S. and Baron, Jeffrey J. and Beekman, Marian M. and Purcell, Shaun S and Voight, Benjamin F Bf and Prokopenko, Inga I. and Demirkan, Ayse Ayşe and Gustafsson, Stefan S. and Ehret, Georg Benedikt Gb and Ried, Janina S. Js and Wilkens, Lynne Lr and Feenstra, Bjarke B. and Ripke, Stephan S. and Van Der Laan, Sander W. and Feitosa, Mary F. and Scholz, Michael M. and de Groot, Lisette C. P. G. M. Lc and Fischer, Krista K. and Shungin, Dmitry D. and Subirana, Isaac I and Van Vliet-Ostaptchouk, Jv and Fraser, Ross M. Rm and Stancáková, Alena A. and Wilensky, Robert R. and Goel, Anuj A. and Van Vliet-Ostaptchouk, Jana V. Jv and Setten, J. van and Gong, Jian J. and Strawbridge, Rona J. Rj and Qasim, Atif A. and Kanoni, Stavroula S. and Vliet-Ostaptchouk, J. V. Van and Sung, Yun Ju YJ and Kleber, Marcus E. Me and Waksman, Ron R. and Tanaka, Toshiko T. and Kristiansson, Kati K. and Satler, Lowell L. and Lim, Unhee U. and Walker, Max C. Mc and Lotay, Vaneet and Waterworth, Dawn M. Dm and Teumer, Alexander A. and Lui, Julian C. Jc and Scheffold, Thomas T. and Mangino, Massimo M. and Estrada, Karol K. and Trompet, Stella S. and The, MIGen Consortium and The, Page Consortium and Medina-Gomez, Carolina C. and Warwick Daw, E. and Nalls, Michael A. and Nyholt, Dale R. Dr and Xie, Changchun C. and Palmer, Cameron D. Cd and Tönjes, Anke and Pasko, Dorota D. and Pechlivanis, Sonali S. and Toenjes, Anke and Siscovick, David D. and Rader, Daniel J Dj and Luan, Jian'An Jian’an and Williams, Rasheeda R. and Spertus, John A Ja and Stark, Klaus K and Ar, Wood and Taylor, Kira K. and Schreiber, Stefan S and Quibrera, Miguel M. and Afzal, Uzma U. and Volzke, Henry and Voelzke, Henry and Arscott, Gillian M. Gm and Thornton-Wells, Tricia T. and Kutalik, Zoltán Zoltán and Bandinelli, Stefania S. and Restrepo, Nicole N. and Barrett, Amy A. and Umans, Jason J. and Bellis, Claire C. and Bennett, Amanda J. Aj and Wilson, Sarah S. and Berne, Christian C. and Spencer, Kylee K. and Blüher, Matthias M. and Bolton, Jennifer L. Jl and Wang, Hansong H. and Böttcher, Yvonne Y. and Shohet, Ralph R. and Boyd, Heather A. Ha and Stram, Daniel D. and Tiirikainen, Maarit M. and Bruinenberg, Marcel M. and Wu, Chunyuan C. and Buckley, Brendan M. Bm and Amin, Najaf N. and Rosse, Stephanie S. and Buyske, Steve Steven and Caspersen, Ida H. Ih and Chines, Peter S. Ps and Clarke, Robert R. and Claudi-Boehm, Simone S. and Cooper, Matthew M. and De Jong, Pim A. Pa and A. E., Justice and Deelen, Joris J. and Delgado, Graciela G. and Denny, Josh C. Jc and van Dijk, Suzanne S. and Dhonukshe-Rutten, Rosalie R. and Justice, Anne E. and van Schoor, Natasja M. Nm and Dimitriou, Maria M. and van der Velde, Nathalie and Doney, Alex Sf F. As and Price, Jackie F. Jf and van Heemst, Diana D. and Leach, Im M. and Dörr, Marcus M. and Daw, Ew Warwick EW and van Oort, Floor Va A. Fv and Eklund, Niina N. and Eury, Elodie E. and Folkersen, Lasse L. and Garcia, Melissa E. Me and Geller, Frank F. and Giedraitis, Vilmantas and Go, Alan S. As and Grallert, Harald H. and Grammer, Tanja B. Tb and Zhang, Qunyuan Qy and Gräßler, Jürgen J. and Th, Pers and Grönberg, Henrik H. and Groves, Christopher J. Cj and Haessler, Jeff Jeffrey and Hall, Per and E., Anne and Haller, Toomas T. and Hallmans, Goran Göran and Peissig, Peggy P. and Hannemann, Anke A. and Hartman, Catharina A. Ca and Hassinen, Maija M. and Hayward, Caroline C. and Mateo Leach, Irene I. and Schumacher, Fr R. and de Faire, Ulf U. and Heard-Costa, Nancy L. Nl and den Ruijter, Hester M. Hm and Kho, Abel N. and Helmer, Quinta Q. and Hemani, Gibran G. and Henders, Anjali K. Ak and Hillege, Hans L. Hl and Johansson, Å. and Hlatky, Mark A. and Hoffmann, Wolfgang W. and Hoffmann, Per P. and Postma, Dirkje S. Ds and Holmen, Oddgeir O. and De Groot, Lisette C. P. G. M. and Houwing-Duistermaat, Jeanine J. Jj and Van Dijk, Suzanne and Illig, Thomas T. and Isaacs, Aaron A. and Van Schoor, Natasja M. and James, Alan L. Al and Jeff, Janina Jarina and Johansen, Berit Bent and Van Der Velde, N. and Jolley, Jennifer J. and Van Heemst, Diana and Van Oort, Floor V. A. and Juliusdottir, Thorhildur T. and Junttila, Juhani J. and Peltonen, Leena L. and Kinnunen, Leena L. and Peyvandi, Flora F. and Klopp, Norman N. and Kocher, Thomas T. and Kratzer, Wolfgang W. and Wilkens, Lr R. and Lichtner, Peter P. and Piazza, Alberto A. and Lind, Lars L. and Arnlov, Johan and Lindström, Jaana J. and Lobbens, Stéphane Stéphane and Rayner, Nigel W. Nw and Johansson, Åsa and Lorentzon, Mattias Matthias and Renstrom, Frida F. and Lu, Yingchang Yc and Lyssenko, Valeriya and Robertson, Neil R. Nr and Magnusson, Patrik Ke E. Pk and Rose, Lynda M. Lm and Peltonen, Leena L and Mahajan, Anubha A. and Roussel, Ronan R. and Maillard, Marc M. and Preuss, Michael M. and McArdle, Wendy L. Wl and Sanna, Serena S. and McKenzie, Colin A. Ca and Scharnagl, Hubert H. and McLachlan, Stela S. and Scholtens, Salome S. and McLaren, Paul J. Pj and Menni, Cristina C. and Schunkert, Heribert H. and Merger, Sigrun S. and Pichard, Augusto D. Ad and Scott, Robert A. Ra and Milani, Lili L. and Moayyeri, Alireza A. and Sehmi, Joban J. and Monda, Keri L. Kl and Seufferlein, Thomas T. and Morken, Mario A. and Shi, Jianxin J. and Müller, Gabriele G. and Müller-Nurasyid, Martina M. and Silventoinen, Karri K. and Musk, Arthur W. Aw and Smit, Johannes H. Jh and Narisu, Narisu N. and Smith, Albert Vernon AV and Nauck, Matthias M. and Preuss, Michael M and Smolonska, Joanna J. and Nolte, Ilja M. Im and Nöthen, Markus M. Mm and Stanton, Alice V. Av and Perusse, Louis and Oozageer, Laticia L. and Stirrups, Kathleen K. and Pilz, Stefan S. and Pérusse, Louis and Stott, David J. Dj and Person, Sharina S. and Stringham, Heather M. Hm and Sundström, Johan J. and Swertz, Morris A. and Syvänen, Ann-Christine Ac and de Bakker, Paul Iw W. Pi and Pendergrass, Sarah S. and Tayo, Bamidele O. 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Ja and Humowiecki, Joel J. and Grönberg, Henrik and Chute, Christopher C. and Law, May M. and van der Harst, Pim P. and Kullo, Iftikar I. and Arnloev, Johan and Koenig, Barbara B. and Bielinski, Suzette S. and Pathak, Jyotishman J. and Zanen, Pieter P. and Henriksen, Joan J. and Blueher, Matthias and Ding, Keyue K. and Arveiler, Dominique D. and Boettcher, Yvonne and Hart, Lacey L. and Bakker, Stephan Jl L. Sj and Palbicki, Jeremy J. and Beilby, John J. and Larson, Eric B. Eb and Newton, Katherine K. and Bergman, Richard N. and Ludman, Evette E. and Bergmann, Sven S. and Hart, Gene G. and Carrell, David D. and Biffar, Reiner R. and van Duijn, Cornelia M. Cm and Jarvik, Gail G. and Blangero, John J. and Crane, Paul P. and Boomsma, Dorret I. Di and Burke, Wylie W. and Bornstein, Stefan R. and Fullerton, Stephanie Malia SM and Carlson, Chris C. and Bovet, Pascal P. and Hutchinson, Fred F. and McDavid, Andrew A. and Brambilla, Paolo P. and Dörr, Marcus and Brown, Morris J. Mj and Doerr, Marcus and Clayton, Ellen E. and Campbell, Harry H. and Haines, Jonathan L. Jl and Caulfield, Mark J. Mj and Chakravarti, Aravinda A. and Masys, Daniel R. Dr and Churchill, Larry R. Lr and Collins, Rory R. and Cornfield, Daniel D. and Collins, Francis S. Fs and Gräßler, Jürgen and Crawford, Dana C. Dc and Graessler, Juergen and Danesh, John J. and Groenberg, Henrik and Van Der Harst, Pim and Crawford, Dana D. and Erbel, Raimund R. and Mckenzie, Colin A. and Erdmann, Jeanette J. and Gronberg, Henrik and Eriksson, Johan G. Jg and Cupples, La Adrienne LA and Farrall, Martin M. and Ferrannini, Ele E. and Darbar, Dawood D. and Ferrières, Jean J. and Ford, Ian I. and Mclachlan, Stela and De Faire, Ulf and Forouhi, Nita G. Ng and Forrester, Terrence T. and Malin, Bradley A. and Den Ruijter, Hm M. and Gansevoort, Ron T. Rt and Gejman, Pablo V. Pv and Denny, Joshua C. Jc and Gieger, Christian C. and Bottcher, Yvonne and Golay, Alain A. and Gottesman, Omri O. and Müller, Gabriele and Gudnason, Vilmundur and Gyllensten, Ulf U. and Müller-Nurasyid, Martina and Haas, David W. Dw and Basford, Melissa M. and Van Duijn, Cm M. and Hall, Alistair S. As and Alizadeh, Behrooz Z. B. and Harris, Tamara B. Tb and Hattersley, Andrew T. At and Boezen, H. Marike HM and Heath, Andrew C. Ac and Hengstenberg, Christian C. and Hicks, Andrew A. Aa and Navis, Gerjan G. and Pagege, Consortium and Hindorff, Lucia A. La and Ormel, Johan J. and Hingorani, Aroon D. Ad and Hofman, Albert A. and Kho, An N. and Lindstroem, Jaana and Humphries, Steve E. Se and Kathiresan, Sekar S. and Hunt, Steven C. Sc and Hypponen, Elina E. and Ardissino, Diego D. and Hovingh, Gk Kees GK and Jacobs, Kevin B. Kb and Tm, Frayling and Musunuru, Kiran K. and Jarvelin, Marjo-Riitta Mr and Qi, Lu L. and Jousilahti, Pekka P. and Mannucci, Pier M. Pm and Jula, Antti M. Am and Raitakari, Olli T. Ot and Anand, Sonia S. and Rankinen, Tuomo T. and Kaprio, Jaakko J. and Kastelein, John Jp P. Jj and Engert, James C. Jc and Rao, Dc C. Dc and Kayser, Manfred M. and Mueller, Gabriele and Rice, Treva K. Tk and Kee, Frank F. and Keinanen-Kiukaanniemi, Sirkka M. Sm and Ritchie, Marylyn D. and Morgan, Thomas T. and Rudan, Igor I. and Kiemeney, Lambertus A. La and Mueller-Nurasyid, Martina and Kooner, Jaspal S. Js and Kho, Abel An and Salomaa, Veikko and Kooperberg, Charles C. and Girelli, Domenico D. and Koskinen, Seppo S. and Samani, Nilesh J. Nj and Noethen, Markus M. and Kovacs, Peter P. and Saramies, Jouko J. and McKeown, Pascal P. Pp and Kraja, Aldi T. At and Sarzynski, Mark A. and Adrienne Cupples, L. and Schwarz, Peter Eh H. Pe and Patterson, Chris C. Cc and Kumari, Meena M. and Kuusisto, Johanna J. and Muller, Gabriele and Sebert, Sylvain S. and Lakka, Timo A. Ta and Nothen, Markus Mm and Sever, Peter P. and Study, LifeLines Cohort and Langenberg, Claudia C. and Shuldiner, Alan R. Ar and Muller-Nurasyid, Martina and Sinisalo, Juha J. and Lehtimäki, Terho T. and O'Donnell, Christopher J. Cj and Steinthorsdottir, Valgerdur and Lupoli, Sara S. and Elosua, Roberto R. and Madden, Pamela Af F. Pa and Melander, Olle O. and Stolk, Ronald P. Rp and Männistö, Satu S. and Merlini, Pier Angelica PA and Le Marchand, Loic L. and Tardif, Jean-Claude Jc and Manunta, Paolo P. and Altshuler, David D. and Tönjes, Anke A. and Marette, André Andre and Tremblay, Angelo A. and Matise, Tara C. Tc and Berzuini, Carlo C. and Tremoli, Elena E. and McKnight, Barbara B. and H. Vermeulen, Sita and Virtamo, Jarmo J. and Ferrario, Maurizio M. and Meitinger, Thomas T. and Vohl, Marie-Claude Mc and Bernardinelli, Luisa L. and Moll, Frans L. Fl and Montgomery, Grant W. Gw and Celli, Patrizia P. and Morris, Andrew D. Ad and Marziliano, Nicola N. and Morris, Andrew P. Ap and Fetiveau, Raffaela R. and Murray, Jeffrey C. Jc and Casari, Giorgio G. and Nelis, Mari M. and Kees Hovingh, G. and Ohlsson, Claes C. and Galli, Michele M. and Oldehinkel, Albertine J. Aj and Bernardi, Francesco F. and Ong, Ken K. Kk and Slagboom, Pe Eline PE and Ouwehand, Willem H. Wh and Friedlander, Yechiel Y. and Consortium, Electronic Medical Records and Genomics (eMEMERGEGE) and Pasterkamp, Gerard G. and Lucas, Gavin G. and Peters, Annette A. and Marrugat, Jaume J. and Pramstaller, Peter P. Pp and Meigs, James B. Jb and Nathan, David M. Dm and Havulinna, Aki S. As and Duga, Stefano S. and MacRae, Calum A. Ca and Wichmann, He-Erich He and Berglund, Goran G. and Asselta, Rosanna R. and Korn, Joshua M. Jm and Marchand, Loic Le and Nemesh, James J. and Daly, Mark J. Mj and Price, Jackie F. and Ardissino, Diego D and Gianniny, Lauren L. and Guiducci, Candace C. and McCarroll, Steven A. Sa and Parkin, Melissa M. and Burtt, Noel N. and Gabriel, Stacey B. Sb and Mirel, Daniel D. and Braund, Peter S. Ps and Loic, Le Marchandm and Records, Electronic Medical and Mannucci, Pier M Pm and Elosua, Roberto R and Balmforth, Anthony J. Aj and Ball, Stephen G. Sg and Pérusse, Louis L. and Kathiresan, Sekar S and Linsel-Nitschke, Patrick P. and Amouyel, Philippe P. and Lieb, Wolfgang W. and Ml, Buchkovich and O'Donnell, Christopher J Cj and Asselbergs, Folkert W. Fw and Fischer, Marcus M. and Melander, Olle O and Assimes, Themistocles L. Tl and Quertermous, Thomas T. and König, Inke R. Ir and Bochud, Murielle Murille and Rauramaa, Rainer R. and Grosshennig, Anika A. and Boehm, Bernhard O. Bo and Hayes, Mg Geoffrey MG and Reinmaa, Eva E. and Boerwinkle, Eric E. and Ks, Lo and Ridker, Paul M. Pm and Musunuru, Kiran K and Bottinger, Erwin P. Ep and Goodall, Alison A. and Bouchard, Claude C. and Rivadeneira, Fernando F. and Ouwehand, Willem W. and Cauchi, Stéphane Stephane and Männistö, Satu and Rotter, Jerome I. Ji and Chambers, John C. Jc and Cambien, Francois F. and Saaristo, Timo E. Te and Chanock, Stephen J. Sj and Saleheen, Danish D. and Mcknight, Barbara and Ae, Locke and Cooper, Richard S. Rs and Schlessinger, David D. and Lucas, Gavin G and Dedoussis, George G. and Chen, Zhen Z. and Ferrucci, Luigi L. and Snieder, Harold H. and Li, Mingyao M. and Spector, Tim D. Td and Mannisto, Satu and Franks, Paul W. Pw and Strauch, Konstantin K. and Matthai, William W. and Froguel, Philippe P. and Stumvoll, Michael M. and De Bakker, Piw I. W. and Laan, S. W. van der and Groop, Leif C. Lc and Tuomilehto, Jaakko J. and Haiman, Christopher A. Ca and Uusitupa, Matti M. and Dc, Croteau Chonka and Hakonarson, Hakon H. Hh and Hamsten, Anders A. and Völzke, Henry H. and Kent, Kenneth M. Km and Devaney, Joe J. and Hui, Jennie J. and Walker, Mark M. and Burnett, Mary-Susan and Hunter, David J. Dj and Wareham, Nicholas J. Nj and Watkins, Hugh H. and Hveem, Kristian K. and Knouff, Christopher W. Cw and Lindsay, Joseph M. Jm and Kaplan, Robert C. Rc and Wilson, James F. Jf and Hayes, Mg Geoff M. and Kivimaki, Mika M. and Jukema, Jw Wouter JW and König, Inke R. I. and Kuh, Diana D. and Mooser, Vincent and Laakso, Markku M. and Liu, Yongmei Ym and Medical, Records The Electronic and Martin, Nicholas G. Ng and Genomics, Consortium and Speliotes, Elizabeth K. Ek and März, Winfried W. and Epstein, Stephen E. Se and Melbye, Mads M. and Thorsteinsdottir, Unnur U. and Cohort, Study The LifeLines and Consortium, MIGen and Moebus, Susanne S. and Hólm, Hilma H. and Munroe, Patricia B. Pb and Do, Ron R. and Njølstad, Inger I. and Geoffrey Hayes, M. and Oostra, Ben A. and Berger, Klaus K. and Palmer, Colin Na A. Cn and Strachan, David P. Dp and Pedersen, Nancy L. Nl and ..,  and Perola, Markus M. and Higashio, Julia J. and Peters, Ulrike U. and Matise, Tara T. and Powell, Joseph E. Je and Au, Jackson and Power, Chris C. and Nato, Andrew A. and Hindorff, Lucia L. and Stefansson, Kari K. and Linsel-Nitschke, Patrick P and Uitterlinden, André G. Ag and Manolio, Teri T. and Huge, Andreas A. and Lieb, Wolfgang W and Fr, Day and Heiss, Gerardo G. and Fischer, Marcus M and Willer, Cristen J. Cj and Ambite, Jose Luis JL and Patterson, Chris C Cc and McKeown, Pascal P Pp and Franceschini, Nora N. and Grosshennig, Anika A and Deelman, Ewa E. and März, Winfried and Eline Slagboom, P. and Martinelli, Nicola N. and Weedon, Michael N. Mn and Corrocher, Roberto R. and Marz, Winfried and Olivieri, Oliviero O. and Avery, Christy C. and Engert, James C Jc and Maerz, Winfried and Lin, Danyu D. and Anand, Sonia S and Graff, Misa M. and Cochran, Barbara B. and MacCluer, Jean J. and Cole, Shelley S. and Visscher, Peter M. 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  doi = {10.1038/ng.3097},
  month = {oct},
  title = {Defining the role of common variation in the genomic and biological architecture of adult human height.},
  url = {http://www.nature.com/articles/ng.3097.pdf},
  year = {2014}
}

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Defining the role of common variation in the genomic and biological architecture of adult human height.

Journal article published in 2014 by Johan Ärnl, Johan Ärnlöv, Mariza M. de Andrade, Rudolf A. Ra de Boer, Melanie M. Mm van der Klauw, M. den Ruijter Hester, Pietro P. Zonzin, Andreas A. Ziegler, I. W. de Bakker Paul, Andreas A Ziegler, Wei W. Zheng, M. van Duijn Cornelia, Weihua W. Zhang, Jean J. Yee, Jean J Yee and other authors. Johan Ärnl, Johan Ärnlöv, Mariza M. de Andrade, Rudolf A. Ra de Boer, Melanie M. Mm van der Klauw, M. den Ruijter Hester, Pietro P. Zonzin, Andreas A. Ziegler, I. W. de Bakker Paul, Andreas A Ziegler, Wei W. Zheng, M. van Duijn Cornelia, Weihua W. Zhang, Jean J. Yee, Jean J Yee, Alicia A. Young, Andrew R. Ar Wood, Zhaoming Z Wang, Zhaoming Z. Wang, Fredrick R. Schumacher, Jing Hua JH Zhao, Fredrick R. Fr Schumacher, Lynne R. Wilkens, Zhaoming Wang, Lynne R. Lr Wilkens, Marylyn M. Ritchie, Justin J. Starren, Z. Wang, Luke L. Rasmussen, Carol C. Waudby, Jonathan J. Reeser, Tune H. Th Pers, Russell A. Ra Wilke, Maureen E. Me Smith, Wendy A. Wa Wolf, Audrey Y. Ay Chu, William K. Wk Thompson, Joshua C. Jc Randall, Tonu Tõnu Esko

, Zm Wang, André Andre Scherag, Jian J. Yang

, Guergana G. Savova, Joel J. Wu, Anna Ae E. Aa Vinkhuyzen, Hoffmannm Wolfgang, Harm-Jan Hj Westra, Martin L. Ml Buchkovich, Leslie L. Spangler, Susan Brown SB Trinidad, Damien C. Dc Croteau-Chonka, Thomas W. Tw Winkler, Dan M. Dm Roden, Felix R. Fr Day

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, Hans L. Hl Hillege, Å. Johansson, Mark A. Hlatky, Wolfgang W. Hoffmann, Per P. Hoffmann, Dirkje S. Ds Postma, Oddgeir O. Holmen, Lisette C. P. G. M. De Groot, Jeanine J. Jj Houwing-Duistermaat, Suzanne Van Dijk, Thomas T. Illig, Aaron A. Isaacs, Natasja M. Van Schoor

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, Reedik Magi, J. Wouter Jukema, Yun Ju Sung, Judith M. Jm Vonk, Catherine A. Ca McCarty, Richard R. Berg, Lindsay L. Ll Waite, James J. Linneman, Yvonne Böttcher, Melanie M. Waldenberger, Aaron A. Miller, Roman R. Wennauer, Vidhu Choudary, Lin L. Chen, Christina C. Willenborg, Terrie T. Kitchner, Tom T. Wilsgaard, Norman N. Fost, Rex L. Rl Chisholm, Mary K. Mk Wojczynski, Pedro C. Pc Avila, Philip P. Greenland, Andrew A. Wong, Johan J. Arnl, Warren A. Wa Kibbe, Alan F. Af Wright, Chu Ay, Amy A. Aa Lemke, William L. Wl Lowe, Jennifer A. Ja Pacheco, Joel J. Humowiecki, Henrik Grönberg, Christopher C. Chute, May M. Law, Pim P. van der Harst, Iftikar I. Kullo, Johan Arnloev, Barbara B. Koenig, Suzette S. Bielinski, Jyotishman J. Pathak, Pieter P. Zanen

, Joan J. Henriksen, Matthias Blueher, Keyue K. Ding, Dominique D. Arveiler, Yvonne Boettcher, Lacey L. Hart, Stephan Jl L. Sj Bakker, Jeremy J. Palbicki, John J. Beilby, Eric B. Eb Larson, Katherine K. Newton, Richard N. Bergman, Evette E. Ludman, Sven S. Bergmann, Gene G. Hart, David D. Carrell, Reiner R. Biffar, Cornelia M. Cm van Duijn, Gail G. Jarvik, John J. Blangero, Paul P. Crane, Dorret I. Di Boomsma, Wylie W. Burke, Stefan R. Bornstein, Stephanie Malia SM Fullerton, Chris C. Carlson, Pascal P. Bovet

, Fred F. Hutchinson, Andrew A. McDavid, Paolo P. Brambilla, Marcus Dörr, Morris J. Mj Brown, Marcus Doerr, Ellen E. Clayton, Harry H. Campbell, Jonathan L. Jl Haines, Mark J. Mj Caulfield, Aravinda A. Chakravarti, Daniel R. Dr Masys, Larry R. Lr Churchill, Rory R. Collins, Daniel D. Cornfield, Francis S. Fs Collins, Jürgen Gräßler, Dana C. Dc Crawford, Juergen Graessler, John J. Danesh, Henrik Groenberg, Pim Van Der Harst, Dana D. Crawford, Raimund R. Erbel, Colin A. Mckenzie, Jeanette J. Erdmann, Henrik Gronberg, Johan G. Jg Eriksson, La Adrienne LA Cupples, Martin M. Farrall, Ele E. Ferrannini, Dawood D. Darbar, Jean J. Ferrières, Ian I. Ford, Stela Mclachlan, Ulf De Faire, Nita G. Ng Forouhi, Terrence T. Forrester, Bradley A. Malin, Hm M. Den Ruijter, Ron T. Rt Gansevoort, Pablo V. Pv Gejman, Joshua C. Jc Denny, Christian C. Gieger

, Yvonne Bottcher, Alain A. Golay, Omri O. Gottesman, Gabriele Müller, Vilmundur Gudnason, Ulf U. Gyllensten, Martina Müller-Nurasyid, David W. Dw Haas, Melissa M. Basford, Cm M. Van Duijn, Alistair S. As Hall, Behrooz Z. B. Alizadeh, Tamara B. Tb Harris, Andrew T. At Hattersley, H. Marike HM Boezen, Andrew C. Ac Heath, Christian C. Hengstenberg, Andrew A. Aa Hicks, Gerjan G. Navis, Consortium Pagege, Lucia A. La Hindorff, Johan J. Ormel, Aroon D. Ad Hingorani, Albert A. Hofman, An N. Kho, Jaana Lindstroem, Steve E. Se Humphries, Sekar S. Kathiresan, Steven C. Sc Hunt, Elina E. Hypponen

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Abstract

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated approximately 2,000, approximately 3,700 and approximately 9,500 SNPs explained approximately 21%, approximately 24% and approximately 29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/beta-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.

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Defining the role of common variation in the genomic and biological architecture of adult human height.

Abstract