Dissemin is shutting down on January 1st, 2025

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Public Library of Science, PLoS ONE, 10(9), p. e109602, 2014

DOI: 10.1371/journal.pone.0109602

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Nicotine Stimulates Nerve Growth Factor in Lung Fibroblasts through an NFκB-Dependent Mechanism

Journal article published in 2014 by Cherry Wongtrakool, Kora Grooms, Kaiser M. Bijli, Kristina Crothers ORCID, Anne M. Fitzpatrick, C. Michael Hart
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Rationale: Airway hyperresponsiveness (AHR) is classically found in asthma, and persistent AHR is associated with poor asthma control. Although airway smooth muscle (ASM) cells play a critical pathophysiologic role in AHR, the paracrine contributions of surrounding cells such as fibroblasts to the contractile phenotype of ASM cells have not been examined fully. This study addresses the hypothesis that nicotine promotes a contractile ASM cell phenotype by stimulating fibroblasts to increase nerve growth factor (NGF) secretion into the environment.