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Springer Nature [academic journals on nature.com], Cell Research, 2(15), p. 92-96, 2005

DOI: 10.1038/sj.cr.7290271

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Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation

Journal article published in 2005 by Amr M. Ghaleb, Mandayam O. Nandan, Sengthong Chanchevalap, W. Brian Dalton, W. Brian Dalton ORCID, Vincent W. Yang, Irfan M. Hisamuddin, W. Yang Vincent
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Krüppel-like factors (KLFs) are evolutionarily conserved zinc finger-containing transcription factors with diverse regulatory functions in cell growth, proliferation, differentiation, and embryogenesis. KLF4 and KLF5 are two closely related members of the KLF family that have a similar tissue distribution in embryos and adults. However, the two KLFs often exhibit opposite effects on regulation of gene transcription, despite binding to similar, if not identical, cis-acting DNA sequences. In addition, KLF4 and 5 exert contrasting effects on cell proliferation in many instances; while KLF4 is an inhibitor of cell growth, KLF5 stimulates proliferation. Here we review the biological properties and biochemical mechanisms of action of the two KLFs in the context of growth regulation.