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Oxford University Press (OUP), Bioinformatics, 10(29), p. 1275-1282

DOI: 10.1093/bioinformatics/btt143

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Shrinkage estimation of dispersion in Negative Binomial models for RNA-seq experiments with small sample size

Journal article published in 2013 by Danni Yu, Wolfgang Huber ORCID, Olga Vitek
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Motivation: RNA-seq experiments produce digital counts of reads that are affected by both biological and technical variation. To distinguish the systematic changes in expression between conditions from noise, the counts are frequently modeled by the Negative Binomial distribution. However, in experiments with small sample size, the per-gene estimates of the dispersion parameter are unreliable.