Published in

Springer Nature [academic journals on nature.com], British Journal of Cancer, 3(84), p. 429-434

DOI: 10.1054/bjoc.2000.1612

Links

Tools

Export citation

Search in Google Scholar

Genetic epidemiology of glioma

Journal article published in 2001 by B. Malmer, L. Iselius, E. Holmberg, A. Collins ORCID, R. Henriksson, H. Grönberg
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

The present study performed a segregation analysis of a cohort of first-degree relatives (FDR) of glioma patients. The families with two or more gliomas were also expanded to determine if any more gliomas could be detected, and if any other types of cancers were associated. These glioma-prone families (n = 24/432) were extended to include first-, second- and third-degree relatives (n = 807) and a cohort was assembled, the standardized incidence risk for other types of cancer calculated and the pedigrees investigated for a possible mode of inheritance. A segregation analysis of the 2141 FDR in 297 families, performed using the Pointer software, did not clearly reject a multifactorial model chi(2)(3) = 6.13, P