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Oxford University Press, FEMS Microbiology Letters, 2(342), p. 79-88, 2013

DOI: 10.1111/1574-6968.12128

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Pre-sporulation stages ofStreptomycesdifferentiation: state-of-the-art and future perspectives

Journal article published in 2013 by Paula Yagüe ORCID, Maria T. López-García, Beatriz Rioseras, Jesús Sánchez, Ángel Manteca
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Streptomycetes comprise very important industrial bacteria, producing two thirds of all clinically relevant secondary metabolites. They are mycelial microorganisms with complex developmental cycles that include programmed cell death (PCD) and sporulation. Industrial fermentations are usually performed in liquid cultures (large bioreactors), conditions in which Streptomyces strains generally do not sporulate and it was traditionally assumed that there was no differentiation. In this work, we review the state-of-the-art regarding Streptomyces pre-sporulation stages of Streptomyces differentiation. © 2013 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.