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Endocrine Society, Molecular Endocrinology -Baltimore-, 8(23), p. 1306-1307, 2009

DOI: 10.1210/mend.23.8.9998

Endocrine Society, Molecular Endocrinology -Baltimore-, 7(23), p. 1125-1125, 2009

DOI: 10.1210/mend.23.7.9996

Oxford University Press, Endocrine Reviews, 5(30), p. 541-541, 2009

DOI: 10.1210/edrv.30.5.9988

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Nerve Growth Factor Induces Vascular Endothelial Growth Factor Expression in Granulosa Cells via a trkA Receptor/Mitogen-Activated Protein Kinase-Extracellularly Regulated Kinase 2-Dependent Pathway

Journal article published in 2009 by Patricia Lozada, Veronica Tapia, Margarita Vega, Marcela Julio-Pieper ORCID, Cristián Miranda, David Vantman, Ojeda Sr, Sergio R. Ojeda, Carmen Romero
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Context: Acquisition of ovulatory competence by antral follicles requires development of an adequate vascular supply. Although it is well established that ovarian angiogenesis is cyclically regulated by vascular endothelial growth factor (VEGF), the factors controlling VEGF production by ovarian follicles remain largely unknown. Nerve growth factor (NGF) may be one of these factors, because NGF promotes angiogenesis and synthesis of angiogenic factors in other tissues and is produced by human granulosa cells (hGCs).