Matrix solid-phase dispersion (MSPD) is a sample-preparation process first introduced in 1989 for the extraction of drug residues from animal tissue. The feasibility and the versatility of MSPD mean it is still widely employed and applicable to a large variety of analytes and samples. The research papers reporting the development of analytical methods with a MSPD-based sample preparation are novel mainly by employing innovative or unusual materials as dispersants and/or the mode of analyte elution. This review gives an update on MSPD from the literature in the period 2012–October 2014, focusing attention on improvements and the outlook for the technique.