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Public Library of Science, PLoS ONE, 12(4), p. e8257, 2009

DOI: 10.1371/journal.pone.0008257

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IFNγ Response to Mycobacterium tuberculosis, Risk of Infection and Disease in Household Contacts of Tuberculosis Patients in Colombia

Journal article published in 2009 by Helena del Corral, Sara C. París, Nancy D. Marín ORCID, Diana M. Marín, Lucelly López, Hanna M. Henao, Teresita Martínez, Liliana Villa, Luis F. Barrera, Blanca L. Ortiz, María E. Ramírez, Carlos J. Montes, María C. Oquendo, Lisandra M. Arango, Felipe Riaño and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Household contacts (HHCs) of pulmonary tuberculosis patients are at high risk of Mycobacterium tuberculosis infection and early disease development. Identification of individuals at risk of tuberculosis disease is a desirable goal for tuberculosis control. Interferon-gamma release assays (IGRAs) using specific M. tuberculosis antigens provide an alternative to tuberculin skin testing (TST) for infection detection. Additionally, the levels of IFNγ produced in response to these antigens may have prognostic value. We estimated the prevalence of M. tuberculosis infection by IGRA and TST in HHCs and their source population (SP), and assessed whether IFNγ levels in HHCs correlate with tuberculosis development.