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Wiley, Macromolecular Bioscience, 5(9), p. 429-436, 2009

DOI: 10.1002/mabi.200800381

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Therapeutic Efficacy of 2-Methoxyestradiol Microcrystals Encapsulated within Polyelectrolyte Multilayers

Journal article published in 2009 by Su He Wang, Xiangyang Shi ORCID, Xisui Chen, James R. Baker
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Development of a novel formulation of anticancer drugs to improve their water-solubility and bioavailability remains a great challenge. Herein, the potential anticancer agent 2-methoxyestradiol (2-ME) was selected as a model drug and was encapsulated within polyelectrolyte (PE) multilayers by layer-by-layer deposition of oppositely charged PEs onto the drug microcrystal surfaces. Cell viability and morphology observation of two cell lines reveal that the PE multilayer-encapsulated 2-ME microcrystals markedly decrease the cell viability, displaying similar inhibitory effect to that of the conventional formulation of 2-ME dissolved in ethanol. The current approach to encapsulate hydrophobic drug microparticles may be useful for formulating different drugs for a variety of biological applications.