Published in

Elsevier, Food and Chemical Toxicology, (61), p. 53-59

DOI: 10.1016/j.fct.2013.01.051

Links

Tools

Export citation

Search in Google Scholar

Resveratrol enhances exercise training responses in rats selectively bred for high running performance

Journal article published in 2013 by Nikolett Hart, Linda Sarga, Zsolt Csende, Erika Koltai, Lauren G. Koch, Steven L. Britton, Kelvin J. A. Davies, Dimitris Kouretas, Barbara Wessner ORCID, Zsolt Radak
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

High capacity runner (HCR) rats have been developed by divergent artificial selection for treadmill endurance running capacity to explore an aerobic biology-disease connection. The beneficial effects of resveratrol supplementation have been demonstrated in endurance running and the antioxidant capacity of resveratrol is also demonstrated. In this study we examine whether 12 weeks of treadmill exercise training and/or resveratrol can enhance performance in HCR. Indeed, resveratrol increased aerobic performance and strength of upper limbs of these rats. Moreover, we have found that resveratrol activated the AMP-activated protein kinase, SIRT1, and mitochondrial transcription factor A (p