Dissemin is shutting down on January 1st, 2025

Published in

Nature Research, Nature Reviews Neuroscience, 3(12), p. 154-167, 2011

DOI: 10.1038/nrn2994

Links

Tools

Export citation

Search in Google Scholar

The Integration of Negative Affect, Pain, and Cognitive Control in the Cingulate Cortex

Journal article published in 2011 by Tim V. Salomons, Alexander J. Shackman ORCID, Heleen A. Slagter, Andrew S. Fox, Jameel J. Winter, Richard J. Davidson ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

It has been argued that emotion, pain and cognitive control are functionally segregated in distinct subdivisions of the cingulate cortex. However, recent observations encourage a fundamentally different view. Imaging studies demonstrate that negative affect, pain and cognitive control activate an overlapping region of the dorsal cingulate--the anterior midcingulate cortex (aMCC). Anatomical studies reveal that the aMCC constitutes a hub where information about reinforcers can be linked to motor centres responsible for expressing affect and executing goal-directed behaviour. Computational modelling and other kinds of evidence suggest that this intimacy reflects control processes that are common to all three domains. These observations compel a reconsideration of the dorsal cingulate's contribution to negative affect and pain.