Published in
Springer (part of Springer Nature), Brain Imaging and Behavior, 3(6), p. 366-373
DOI: 10.1007/s11682-012-9149-4
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- [www.ncbi.nlm.nih.gov] | PDF
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- [www.ncbi.nlm.nih.gov] | PDF
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Functional Connectivity Measured with Magnetoencephalography Identifies Persons with HIV Disease
,
Ricardo Bajo,
Melissa Fabrizio,
Gustavo Sudre,
Pablo Cuesta,
Howard J. Aizenstein,
Oscar L. Lopez,
David Wolk,
Lauri Parkkonen,
Fernando Maestu,
Anto Bagic
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Abstract
There is need for a valid and reliable biomarker for HIV Associated Neurocognitive Disorder (HAND). The purpose of the present study was to provide preliminary evidence of the potential utility of neuronal functional connectivity measures obtained using magnetoencephalography (MEG) to identify HIV-associated changes in brain function. Resting state, eyes closed, MEG data from 10 HIV-infected individuals and 8 seronegative controls were analyzed using mutual information (MI) between all pairs of MEG sensors to determine whether there were functional brain networks that distinguished between subject groups based on cognition (global and learning) or on serostatus.