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Elsevier, Experimental Gerontology, (72), p. 162-166, 2015

DOI: 10.1016/j.exger.2015.09.019

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Do telomeres have a higher plasticity than thought? Results from the German Chronic Kidney Disease (GCKD) study as a high-risk population

Journal article published in 2015 by R. Zitzmann, M. Zeier, G. Wolf, Helena Zacharias, Julia Raschenberger, A. Kottgen, H. Meiselbach, Barbara Kollerits, M. Schneider, T. Dienemann, H. U. Prokosch, A. Reis, Stephanie Titze, O. Gefeller, K. F. Hilgers and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Telomere length is considered as a biological marker for aging. It is expected that telomeres shorten with age and with conditions associated with oxidative stress and inflammation. Both are present in patients with chronic kidney disease (CKD) who have a very high cardiovascular risk. We investigated whether CKD duration is associated with relative telomere length (RTL) in 4802 patients from the German Chronic Kidney Disease (GCKD) study. We measured RTL in each sample in quadruplicates using a quantitative polymerase chain reaction (qPCR). We observed a U-shaped association of RTL with CKD duration: the longest RTL was found in those 339 patients who reported the shortest disease duration (