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Elsevier, Environmental Research, (142), p. 264-272

DOI: 10.1016/j.envres.2015.07.003

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Urinary biomarkers of exposure and of oxidative damage in children exposed to low airborne concentrations of benzene

Journal article published in 2015 by R. Andreoli, G. Spatari ORCID, D. Pigini, D. Poli, I. Banda, I. I. Banda, M. Goldoni ORCID, Mg G. Riccelli, M. Petyx, C. Protano, M. Vitali, M. Barbaro, A. Mutti
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

The aim of this work was to evaluate the oxidative damage to nucleic acids in children (5-11 years) associated with exposure to environmental pollutants and tobacco smoke (ETS). For each subject, urinary sampling was done twice (evening and next morning) to measure by tandem LC-MS-MS such oxidated products of nucleic acids as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo), 8-oxo-7,8-dihydroguanosine (8-oxoGuo), and 8-oxo-7,8-dihydroguanine (8-oxoGua). Methyl tert-butyl ether (U-MTBE), benzene (U-Benz), and its metabolites (t,t-muconic and S-phenylmercapturic acids, t,t-MA and S-PMA, respectively) were determined as biomarkers of exposure to air pollution, and cotinine as a biomarker of exposure to ETS. Biomarkers of exposure (S-PMA and U-MTBE) and of DNA oxidation (8-oxodGuo) were dependent on the urbanization and industrialization levels and increased in the evening sample as compared to next morning (p