Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 8(52), p. 2940-2942, 2008
DOI: 10.1128/aac.01581-07
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In Vitro Activity of Tigecycline against Multidrug-Resistant Acinetobacter baumannii and Selection of Tigecycline-Amikacin Synergy
Journal article published in 2008 by
Ellen S. Moland,
David W. Craft,
Seong-Geun Hong 
,
Soo-Young Kim,
Lucas Hachmeister,
Shimon D. Sayed,
Kenneth S. Thomson
,
Soo-Young Kim,
Lucas Hachmeister,
Shimon D. Sayed,
Kenneth S. Thomson
This paper is made freely available by the publisher.
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Abstract
ABSTRACT Polymyxin B, minocycline, and tigecycline were the most potent of 10 antibiotics against 170 isolates of multidrug-resistant Acinetobacter baumannii . In time-kill studies, the exposure of a highly tigecycline-resistant isolate to tigecycline resulted in enhanced susceptibility to amikacin and synergistic bactericidal activities of the two drugs.