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BioMed Central, BMC Infectious Diseases, 1(15), 2015

DOI: 10.1186/s12879-015-0964-2

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Psychological distress and its relationship with non-adherence to TB treatment: a multicentre study

Journal article published in 2015 by Grant Theron, Jonny Peter, Lynn Zijenah, Duncan Chanda, Chacha Mangu, Petra Clowes, Andrea Rachow, Maia Lesosky ORCID, Michael Hoelscher, Alex Pym, Peter Mwaba, Peter Mason, Pamela Naidoo, Anil Pooran, Hojoon Sohn and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background The successful cure of tuberculosis (TB) is dependent on adherence to treatment. Various factors influence adherence, however, few are easily modifiable. There are limited data regarding correlates of psychological distress and their association with non-adherence to anti-TB treatment. Methods In a trial of a new TB test, we measured psychological distress (K-10 score), TB-related health literacy, and morbidity (TBscore), prior to diagnosis in 1502 patients with symptoms of pulmonary TB recruited from clinics in Cape Town ( n = 419), Harare ( n = 400), Lusaka ( n = 400), Durban ( n = 200), and Mbeya ( n = 83). Socioeconomic, demographic, and alcohol usage-related data were captured. Patients initiated on treatment had their DOTS cards reviewed at two-and six-months. Results 22 %(95 % CI: 20 %, 25 %) of patients had severe psychological distress (K-10 ≥ 30). In a multivariable linear regression model, increased K-10 score was independently associated with previous TB [estimate (95 % CI) 0.98(0.09-1.87); p = 0.0304], increased TBscore [1(0.80, 1.20); p